Reactome | BANP binds TP53

BANP binds TP53

Stable Identifier

R-HSA-3221982

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        BANP binds TP53 (Homo sapiens)

General

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BANP (SMAR1) binds TP53 (p53) and is implicated in both positive (Kaul et al. 2003, Jalota et al. 2005) and negative regulation of TP53 transcriptional activity (Pavithra et al. 2009, Sinha et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15701641	Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif Jalota, A, Pavithra, L, Kaul-Ghanekar, R, Singh, K, Jameel, S, Chattopadhyay, S	J. Biol. Chem.	2005
19303885	SMAR1 forms a ternary complex with p53-MDM2 and negatively regulates p53-mediated transcription Sakaguchi, K, Sreenath, K, Mukherjee, S, Pavithra, L, Roy, S, Kar, S, Chattopadhyay, S	J. Mol. Biol.	2009
20075864	Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element Mukhopadhyaya, R, Mittal, SP, Pal, JK, Sinha, S, Kamat, R, Singh, K, Chattopadhyay, S, Malonia, SK, Kadreppa, S	EMBO J.	2010
12494467	Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice Bhat, MK, Chhipa, R, Galande, S, Kaul, R, Chattopadhyay, S, Ahmed, F, Mukherjee, S	Int. J. Cancer	2003