COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77

Stable Identifier
R-HSA-3215426
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77
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The histone-binding protein cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008).

Literature References
PubMed ID Title Journal Year
18404153 The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Lacroix, M, El Messaoudi, S, Rodier, G, Le Cam, A, Sardet, C, Fabbrizio, E

EMBO Rep. 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)
Authored
Jupe, S  (2013-03-12)
Reviewed
Guccione, E  (2014-05-09)
Fischle, W  (2014-07-23)
Created
Jupe, S  (2013-03-15)