Reactome | COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77

COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77

Stable Identifier

R-HSA-3215426

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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The histone-binding protein cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18404153	The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5 Rodier, G, Le Cam, A, Fabbrizio, E, Sardet, C, El Messaoudi, S, Lacroix, M	EMBO Rep.	2008