COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77

Stable Identifier
R-HSA-3215426
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The histone-binding protein cooperator of PRMT5 (COPRS) guides PRMT5:WDR77 to methylate histone H4 arginine-4 (H4R3) rather than histone H3 arginine-9 (H3R8) (Lacroix et al. 2008).

Literature References
PubMed ID Title Journal Year
18404153 The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5

Lacroix, M, El Messaoudi, S, Rodier, G, Le Cam, A, Sardet, C, Fabbrizio, E

EMBO Rep. 2008
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Canis familiaris)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Mus musculus)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Rattus norvegicus)
Authored
Jupe, S  (2013-03-12)
Reviewed
Guccione, E  (2014-05-09)
Fischle, W  (2014-07-23)
Created
Jupe, S  (2013-03-15)
Cite Us!