USP7 deubiquitinates TP53 and counteracts MDM2

Stable Identifier
R-HSA-3215310
Type
Reaction
Species
Homo sapiens
Compartment
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USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).

Literature References
PubMed ID Title Journal Year
16402859 Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway

Gu, L, Shi, Y, Gu, W, Jeffrey, PD, Hu, M, Li, M

PLoS Biol. 2006
11923872 Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Gu, W, Luo, J, Nikolaev, AY, Shiloh, A, Chen, D, Qin, J, Li, M

Nature 2002
16474402 Molecular recognition of p53 and MDM2 by USP7/HAUSP

Arrowsmith, CH, Duan, S, Sheng, Y, Sarkari, F, Frappier, L, Wu, T, Saridakis, V

Nat. Struct. Mol. Biol. 2006
15053880 A dynamic role of HAUSP in the p53-Mdm2 pathway

Gu, W, Brooks, CL, Kon, N, Li, M

Mol. Cell 2004
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of USP7 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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