Reactome | USP7 deubiquitinates TP53 and counteracts MDM2

USP7 deubiquitinates TP53 and counteracts MDM2

Stable Identifier

R-HSA-3215310

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        USP7 deubiquitinates TP53 and counteracts MDM2 (Homo sapiens)

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USP7 deubiquitinates TP53 and counteracts MDM2

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USP7 (HAUSP) can deubiquitinate TP53, thereby prolonging TP53 half-life and enhancing TP53 activity (Li et al. 2002, Li et al. 2004, Sheng et al. 2006, Hu et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16402859	Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway Hu, M, Gu, L, Li, M, Jeffrey, PD, Gu, W, Shi, Y	PLoS Biol.	2006
11923872	Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization Li, M, Chen, D, Shiloh, A, Luo, J, Nikolaev, AY, Qin, J, Gu, W	Nature	2002
16474402	Molecular recognition of p53 and MDM2 by USP7/HAUSP Sheng, Y, Saridakis, V, Sarkari, F, Duan, S, Wu, T, Arrowsmith, CH, Frappier, L	Nat. Struct. Mol. Biol.	2006
15053880	A dynamic role of HAUSP in the p53-Mdm2 pathway Li, M, Brooks, CL, Kon, N, Gu, W	Mol. Cell	2004