Reactome | ING5 [nucleoplasm]

ING5 [nucleoplasm]

Stable Identifier

R-HSA-3215169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Inhibitor of growth protein 5, p28ING5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        ING5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WYH8 ING5

Gene Names

ING5

Chain

chain:1-240

Reference Genes

BioGPS Gene:84289 ING5

COSMIC (genes):ING5 ING5

CTD Gene:84289 ING5

dbSNP Gene:84289 ING5

ENSEMBL:ENSG00000168395 ING5

HGNC:19421 ING5

KEGG:hsa:84289 ING5

Monarch:84289 ING5

NCBI Gene:84289 ING5

OMIM:608525 ING5

UCSC:Q8WYH8 ING5

Reference Transcript

Participates

as a component of

Inferred To

ing5 [nucleoplasm] (Xenopus tropicalis)

PHO23 [nucleoplasm] (Saccharomyces cerevisiae)

ING5 [nucleoplasm] (Bos taurus)

ING5 [nucleoplasm] (Canis familiaris)

ING5 [nucleoplasm] (Gallus gallus)

ING5 [nucleoplasm] (Sus scrofa)

ing5a [nucleoplasm] (Danio rerio)

Ghost homologue of ING5 [nucleoplasm] (Caenorhabditis elegans)

Homologues of ING5 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of ING5 [nucleoplasm] (Schizosaccharomyces pombe)

YNG2 [nucleoplasm] (Saccharomyces cerevisiae)

png2 [nucleoplasm] (Schizosaccharomyces pombe)

png1 [nucleoplasm] (Schizosaccharomyces pombe)

Ing5 [nucleoplasm] (Drosophila melanogaster)

Ing5 [nucleoplasm] (Mus musculus)

Ing5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001317091.1, NP_115705.2, XP_054200158.1, XP_047301969.1

ENSEMBL

ENST00000313552, ENSP00000322142, ENSP00000385937, ENST00000406941, ENSG00000168395

OpenTargets

ENSG00000168395

GeneCards

ING5

HPA

ENSG00000168395-ING5

PRO

Q8WYH8

Pharos - Targets

Q8WYH8

PDB

5ME8, 3C6W, 5MTO

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.718	6
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.547	2
UniProt:Q92794 KAT6A	3	KAT6A [nucleoplasm] (R-HSA-480310) p-T369-KAT6A [nucleoplasm] (R-HSA-6805633) KAT6A [nucleoplasm] (R-HSA-5603260)	0.527	4