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TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter
Stable Identifier
R-HSA-3215152
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TP53, together with chromatin modifying enzymes EP300, PRMT1 and CARM1, binds the p53 response element in the third intron of the GADD45A gene (An et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15186775
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53
Kim, J
,
Roeder, RG
,
An, W
Cell
2004
Participants
Input
CARM1 [nucleoplasm]
(Homo sapiens)
EP300 [nucleoplasm]
(Homo sapiens)
GADD45A gene [nucleoplasm]
(Homo sapiens)
p-S15,S20-TP53 Tetramer [nucleoplasm]
(Homo sapiens)
PRMT1 [nucleoplasm]
(Homo sapiens)
Output
p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest (Homo sapiens)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2013-03-15)
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