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TCF3 [nucleoplasm]
Stable Identifier
R-HSA-3209896
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor E2-alpha, TFE2_HUMAN, E2A, E47
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Gene Transcription (Homo sapiens)
Negative Regulation of CDH1 Gene Transcription (Homo sapiens)
TCF3 binds CDH1 gene promoter (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
TCF3:CDH1 gene [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
TCF3 represses CDH1 gene transcription (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
TCF3:CDH1 gene [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Myogenesis (Homo sapiens)
Phosphorylation of E proteins by p38 MAPK (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1 binds the core TAL1 complex (Homo sapiens)
RUNX1:CBFB:TAL1 core complex [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1-containing TAL1 complex binds the MYB gene enhancer (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
GATA3-TAL1 core complex [nucleoplasm] (Homo sapiens)
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
TCF3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15923 TCF3
Gene Names
TCF3, BHLHB21, E2A, ITF1
Chain
chain:1-654
Reference Genes
BioGPS Gene:6929 TCF3
COSMIC (genes):TCF3 TCF7L1
CTD Gene:6929 TCF3
dbSNP Gene:6929 TCF3
ENSEMBL:ENSG00000071564 TCF3
HGNC:11633 TCF3
KEGG:hsa:6929 TCF3
Monarch:6929 TCF3
NCBI Gene:6929 TCF3
OMIM:147141 TCF3
UCSC:P15923 TCF3
Reference Transcript
RefSeq:XM_017027180.1 TCF3
RefSeq:XM_017027181.2 TCF3
RefSeq:XM_047439269.1 TCF3
RefSeq:XM_054321875.1 TCF3
RefSeq:XM_054321873.1 TCF3
RefSeq:XM_054321863.1 TCF3
RefSeq:XM_054321868.1 TCF3
RefSeq:NM_001351779.2 TCF3
RefSeq:NM_001136139.4 TCF3
RefSeq:XM_017027182.1 TCF3
RefSeq:XM_054321865.1 TCF3
RefSeq:XM_047439276.1 TCF3
RefSeq:XM_047439283.1 TCF3
RefSeq:XM_047439264.1 TCF3
RefSeq:XM_054321867.1 TCF3
RefSeq:XM_047439281.1 TCF3
RefSeq:XM_047439282.1 TCF3
RefSeq:XM_047439277.1 TCF3
RefSeq:XM_054321866.1 TCF3
RefSeq:XM_054321864.1 TCF3
RefSeq:XM_047439278.1 TCF3
RefSeq:XM_047439284.1 TCF3
RefSeq:XM_054321877.1 TCF3
RefSeq:XM_054321876.1 TCF3
RefSeq:XM_047439265.1 TCF3
RefSeq:XM_047439263.1 TCF3
RefSeq:XM_054321874.1 TCF3
RefSeq:XM_054321862.1 TCF3
RefSeq:XM_054321872.1 TCF3
RefSeq:NM_003200.5 TCF3
RefSeq:XM_047439268.1 TCF3
Participates
as an input of
Phosphorylation of E proteins by p38 MAPK (Homo sapiens)
TCF3 binds CDH1 gene promoter (Homo sapiens)
as a member of
TCF3,TCF12 [nucleoplasm] (Homo sapiens)
as a component of
TCF3:CDH1 gene [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S139-TCF3 [nucleoplasm]
Inferred To
da [nucleoplasm]
(Drosophila melanogaster)
hlh-2 [nucleoplasm]
(Caenorhabditis elegans)
Tcf3 [nucleoplasm]
(Mus musculus)
Tcf3 [nucleoplasm]
(Rattus norvegicus)
tcf3b [nucleoplasm]
(Danio rerio)
TCF3 [nucleoplasm]
(Bos taurus)
TCF3 [nucleoplasm]
(Canis familiaris)
TCF3 [nucleoplasm]
(Gallus gallus)
TCF3 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
XP_054177849.1
,
XP_054177841.1
,
XP_016882670.1
,
NP_001338708.1
,
XP_054177847.1
,
XP_054177840.1
,
XP_054177848.1
,
XP_054177842.1
,
XP_054177843.1
,
XP_047295225.1
,
XP_047295224.1
,
XP_047295220.1
,
XP_047295221.1
,
XP_047295240.1
,
XP_047295237.1
,
XP_047295234.1
,
NP_003191.1
,
XP_047295232.1
,
XP_047295233.1
,
XP_054177851.1
,
XP_054177852.1
,
XP_016882669.1
,
XP_016882671.1
,
XP_047295239.1
,
XP_054177837.1
,
XP_047295219.1
,
XP_047295238.1
,
XP_054177838.1
,
XP_054177850.1
,
XP_054177839.1
,
NP_001129611.1
OpenTargets
ENSG00000071564
ENSEMBL
ENSP00000262965
,
ENST00000588136
,
ENSG00000071564
,
ENSP00000378813
,
ENSP00000468487
,
ENST00000262965
,
ENST00000395423
HPA
ENSG00000071564-TCF3
GeneCards
TCF3
PRO
P15923
Pharos - Targets
P15923
Orphanet
TCF3
GlyGen
P15923
PDB
2YPB
,
2MH0
,
6MGN
,
3U5V
,
2YPA
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17542 TAL1
1
TAL1 [nucleoplasm]
(R-HSA-8956511)
0.876
10
UniProt:Q02363 ID2
1
ID2 [nucleoplasm]
(R-HSA-452391)
0.669
3
UniProt:P50553 ASCL1
1
ASCL1 [nucleoplasm]
(R-HSA-212402)
0.632
4
UniProt:Q02535 ID3
1
ID3 [nucleoplasm]
(R-HSA-9613379)
0.556
3
UniProt:Q9Y4C2 TCAF1
0.556
3
UniProt:Q02577 HEN2
0.527
3
UniProt:Q92886 NGN1
0.527
2
UniProt:Q9Y4Z2 NEUROG3
1
NEUROG3 [nucleoplasm]
(R-HSA-189530)
0.527
3
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