ERF inhibits ETS2 expression

Stable Identifier
R-HSA-3209179
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ERF inhibits ETS2 expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of ERF to ETS2 promoter strongly represses ETS2 transcription (Sgouras et al. 1995).

Literature References
PubMed ID Title Journal Year
7588608 ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

Mavrothalassitis, GJ, Fisher, RJ, Blair, DG, Athanasiou, MA, Beal, GJ, Sgouras, DN

EMBO J. 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
ERF:ETS2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
ERF [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-02)
Cite Us!