Phosphorylated ERF translocates to the cytosol

Stable Identifier
R-HSA-3209159
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated ERF translocates to the cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation of ERF at threonine T526 by activated ERKs triggers ERF export from the nucleus to the cytosol (Le Gallic et al. 2004), which is expected to relieve ERF-mediated inhibition of ETS2 transcription.

Literature References
PubMed ID Title Journal Year
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Cohen, P, Mavrothalassitis, G, Le Gallic, L, Biteau, B, Virgilio, L

Mol. Cell. Biol. 2004
Participants
Input
Output
Participates
as an event of
Orthologous Events
Phosphorylated ERF translocates to the cytosol (Bos taurus)
Phosphorylated ERF translocates to the cytosol (Canis familiaris)
Phosphorylated ERF translocates to the cytosol (Danio rerio)
Phosphorylated ERF translocates to the cytosol (Gallus gallus)
Phosphorylated ERF translocates to the cytosol (Mus musculus)
Phosphorylated ERF translocates to the cytosol (Rattus norvegicus)
Phosphorylated ERF translocates to the cytosol (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
Cite Us!