Phosphorylated ERF translocates to the cytosol

Stable Identifier
R-HSA-3209159
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Phosphorylated ERF translocates to the cytosol
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Phosphorylation of ERF at threonine T526 by activated ERKs triggers ERF export from the nucleus to the cytosol (Le Gallic et al. 2004), which is expected to relieve ERF-mediated inhibition of ETS2 transcription.

Literature References
PubMed ID Title Journal Year
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Cohen, P, Mavrothalassitis, G, Le Gallic, L, Biteau, B, Virgilio, L

Mol. Cell. Biol. 2004
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
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