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Translation of p14ARF mRNA is inhibited by miR-24
Stable Identifier
R-HSA-3209111
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Oncogene Induced Senescence (Homo sapiens)
Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Translation of p14ARF mRNA is inhibited by miR-24 (Homo sapiens)
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MicroRNA miR-24 inhibits translation of p14ARF mRNA without causing mRNA degradation. This results in high p14ARF transcript level accompanied by low p14ARF protein level (To et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22336108
Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development
Thériault, BL
,
Gallie, BL
,
To, KH
,
Pajovic, S
BMC Cancer
2012
Participants
Input
p14ARF mRNA [cytosol]
(Homo sapiens)
Output
p14ARF [cytosol]
(Homo sapiens)
Participates
as an event of
Oxidative Stress Induced Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
This event is regulated
Negatively by
Regulator
p16INK4A/p14ARF mRNA: miR-24 Nonendonucleolytic RISC [cytosol]
(Homo sapiens)
Active Unit
miR-24 Nonendonucleolytic RISC [cytosol]
Authored
Orlic-Milacic, M (2013-07-15)
Reviewed
Samarajiwa, S (2013-09-03)
Created
Orlic-Milacic, M (2013-03-01)
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