Reactome | NR1I2-2 [nucleoplasm]

NR1I2-2 [nucleoplasm]

Stable Identifier

R-HSA-3196181

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor subfamily 1 group I member 2 isoform 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75469-2 NR1I2

Gene Names

NR1I2, PXR

Participates

as a candidate of

NR [nucleoplasm] (Homo sapiens)

Inferred To

NR1I2-1 [nucleoplasm] (Mus musculus)

NR1I2-1 [nucleoplasm] (Rattus norvegicus)

nhr-48 [nucleoplasm] (Caenorhabditis elegans)

NR1I2 [nucleoplasm] (Bos taurus)

NR1I2 [nucleoplasm] (Canis familiaris)

NR1I2 [nucleoplasm] (Sus scrofa)

nr1i2 [nucleoplasm] (Danio rerio)

Hr96 [nucleoplasm] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

606

OpenTargets

ENSG00000144852

ENSEMBL

ENSP00000420297, ENST00000393716, ENSG00000144852, ENST00000466380, ENSP00000336528, ENSP00000377319, ENST00000337940

ZINC - FDA approved

NR1I2_HUMAN

ZINC - Substances

NR1I2_HUMAN

ZINC - Biogenic

NR1I2_HUMAN

ZINC target

O75469

PRO

O75469

PDB

4X1F, 7AXG, 7AXJ, 7AXB, 5A86, 7AX8, 7AXH, 4X1G, 7YFK, 7AXA, 6TFI, 8E3N, 6XP9, 1ILH, 7AXL, 7AXE, 1M13, 1NRL, 1SKX, 4S0S, 8CCT, 8SVS, 8SVU, 6BNS, 8SVP, 8SZV, 8SVT, 8SVQ, 3HVL, 7RIU, 6DUP, 6HJ2, 8EQZ, 4J5X, 8F5Y, 8CF9, 4XHD, 7AXF, 4J5W, 7AXK, 3R8D, 7AXC, 5X0R, 6P2B, 7AXI, 4XAO, 7AX9, 1ILG, 2O9I, 3CTB, 7AXD, 6NX1, 6HTY, 8FPE, 4S0T, 8CH8, 4NY9, 8SVN, 7N2A, 7RIO, 2QNV, 8SVX, 9BEQ, 8SVO, 8SVR, 6S41, 7RIV

ZINC - Investigational

NR1I2_HUMAN

ZINC - Metabolites

NR1I2_HUMAN

HPA

ENSG00000144852-NR1I2

GeneCards

NR1I2

Pharos - Targets

O75469

ZINC - Predictions - Purchasable

NR1I2_HUMAN

HMDB Protein

HMDBP02048

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.602	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.524	2

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