Reactome | PGR-2 [nucleoplasm]

PGR-2 [nucleoplasm]

Stable Identifier

R-HSA-3196176

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Progesterone receptor isoform 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P06401-2 PGR

Gene Names

PGR, NR3C3

Other Identifiers

0101990537

11726167_a_at

11726168_at

11750900_a_at

11750901_x_at

160021_r_at

16743577

208305_PM_at

208305_at

228554_PM_at

228554_at

3388369

3388370

3388371

3388372

3388373

3388374

3388375

3388376

3388377

3388378

3388379

3388380

3388382

3388383

3388387

3388393

3388407

3388408

3388410

3388411

3388412

3388413

3388414

3388415

426_at

44598_at

5241

7951165

81847_at

83526_at

A_23_P138938

A_32_P49199

GE59760

GE630055

GE900767

GO:0000785

GO:0000978

GO:0000981

GO:0001223

GO:0001228

GO:0001542

GO:0002070

GO:0002071

GO:0003674

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005102

GO:0005496

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0007165

GO:0007267

GO:0008134

GO:0008150

GO:0008270

GO:0008289

GO:0010628

GO:0010629

GO:0016020

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030518

GO:0030879

GO:0038001

GO:0042802

GO:0043167

GO:0043226

GO:0043401

GO:0043565

GO:0045944

GO:0046872

GO:0048286

GO:0048856

GO:0050678

GO:0050847

GO:0051117

GO:0060748

HMNXSV003001822

HMNXSV003041440

Hs.32405.0.S1_3p_at

ILMN_1811014

PH_hs_0000369

PH_hs_0002738

TC11002220.hg

TC11003308.hg

TC11003309.hg

X51730_at

g4505766_3p_at

Participates

as a candidate of

NR [nucleoplasm] (Homo sapiens)

Inferred To

ERR [nucleoplasm] (Drosophila melanogaster)

PGR [nucleoplasm] (Bos taurus)

PGR [nucleoplasm] (Canis familiaris)

PGR [nucleoplasm] (Danio rerio)

PGR [nucleoplasm] (Gallus gallus)

PGR [nucleoplasm] (Sus scrofa)

Pgr [nucleoplasm] (Mus musculus)

Pgr [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001189403.1, NP_001258091.1, NP_001258090.1, NP_000917.3

ZINC - World Drugs

PRGR_HUMAN

Guide to Pharmacology - Targets

627

OpenTargets

ENSG00000082175

ZINC - FDA approved

PRGR_HUMAN

ZINC - Substances

PRGR_HUMAN

ZINC target

P06401

ZINC - Biogenic

PRGR_HUMAN

PRO

P06401

PDB

3KBA, 3D90, 3ZR7, 3ZRA, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3HQ5, 3ZRB, 4OAR, 1E3K, 1SQN, 5CC0, 3G8O, 1SR7, 4A2J, 4APU, 1A28

ZINC - Investigational

PRGR_HUMAN

ZINC - Metabolites

PRGR_HUMAN

HPA

ENSG00000082175-PGR

GeneCards

P06401

Ensembl

ENST00000534013, ENSP00000436561, ENST00000263463, ENST00000325455, ENSG00000082175, ENSP00000263463, ENSP00000325120

Pharos - Targets

P06401

ZINC - Predictions - Purchasable

PRGR_HUMAN

Orphanet

24806

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [cytosol] (R-HSA-9020974) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.774	20
UniProt:Q9H467 CUED2			0.66	9
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.623	3
UniProt:P06401 PGR	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [cytosol] (R-HSA-8948964) PGR [nucleoplasm] (R-HSA-3008952)	0.623	2
IntAct:EBI-2119323 CCND1			0.527	5
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.462	2