Reactome | NR1I2-6 [nucleoplasm]

NR1I2-6 [nucleoplasm]

Stable Identifier

R-HSA-3196160

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor subfamily 1 group I member 2 isoform 6

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O75469-6 NR1I2

Gene Names

NR1I2, PXR

Other Identifiers

0000540632

0001240528

11738805_a_at

11740333_a_at

16944464

207202_PM_s_at

207202_s_at

207203_PM_s_at

207203_s_at

2638176

2638178

2638179

2638180

2638181

2638182

2638183

2638184

2638185

2638186

2638190

2638191

2638192

2638198

2638201

2638202

2638203

2638206

2638208

2638209

2638212

2638213

2638214

2638215

35114_at

8081925

8856

A_14_P132184

A_23_P109785

GE55185

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005856

GO:0006351

GO:0006355

GO:0006629

GO:0006805

GO:0007165

GO:0008202

GO:0008270

GO:0010628

GO:0016604

GO:0016922

GO:0023052

GO:0030154

GO:0030522

GO:0032991

GO:0042178

GO:0042908

GO:0043226

GO:0043565

GO:0045111

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0060089

GO:1990837

HMNXSV003033700

ILMN_1715231

ILMN_1806561

ILMN_2240109

ILMN_2323338

PH_hs_0006489

TC03000613.hg

g11863133_3p_a_at

g3511137_3p_a_at

Participates

as a candidate of

NR [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of NR1I2-1 [nucleoplasm] (Caenorhabditis elegans)

nhr-8 [nucleoplasm] (Caenorhabditis elegans)

NR1I2-1 [nucleoplasm] (Canis familiaris)

NR1I2-1 [nucleoplasm] (Danio rerio)

NR1I2-1 [nucleoplasm] (Mus musculus)

NR1I2-1 [nucleoplasm] (Rattus norvegicus)

daf-12 [nucleoplasm] (Caenorhabditis elegans)

nhr-48 [nucleoplasm] (Caenorhabditis elegans)

NR1I2 [nucleoplasm] (Bos taurus)

NR1I2 [nucleoplasm] (Sus scrofa)

Hr96 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_003880.3, NP_071285.1, NP_148934.1

ZINC - World Drugs

NR1I2_HUMAN

Guide to Pharmacology - Targets

606

OpenTargets

ENSG00000144852

ZINC - FDA approved

NR1I2_HUMAN

ZINC - Substances

NR1I2_HUMAN

ZINC - Biogenic

NR1I2_HUMAN

ZINC target

O75469

PRO

O75469

PDB

3HVL, 7AXD, 4S0T, 7RIV, 1M13, 6DUP, 5A86, 6P2B, 1NRL, 4XHD, 7AXG, 7RIO, 6XP9, 2O9I, 7AXJ, 7AXH, 6HTY, 7AXL, 7AXE, 3R8D, 5X0R, 7AXC, 4S0S, 4X1F, 7AXK, 4NY9, 7AXI, 6BNS, 7AXA, 4XAO, 6NX1, 6S41, 7AX8, 1ILG, 7CHG, 7N2A, 4J5W, 2QNV, 7RIU, 4X1G, 7AX9, 7AXF, 6TFI, 1SKX, 1ILH, 7AXB, 3CTB, 6HJ2, 4J5X

ZINC - Investigational

NR1I2_HUMAN

ZINC - Metabolites

NR1I2_HUMAN

HPA

ENSG00000144852-NR1I2

GeneCards

O75469

Ensembl

ENST00000393716, ENSP00000377319, ENST00000337940, ENSP00000336528, ENST00000466380, ENSG00000144852, ENSP00000420297

Pharos - Targets

O75469

Orphanet

24765

ZINC - Predictions - Purchasable

NR1I2_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.602	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2