cob(II)alamin dissociates from MMACHC:MMADHC

Stable Identifier
R-HSA-3149492
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Exact details are unclear but it is assumed once the binding proteins (MMADCHC and MMADHC) deliver cob(II)alamin (B12r) to its cytosolic destination, they dissociate from it (Mah et al. 2013, Plesa et al. 2011, Deme et al. 2012).

Literature References
PubMed ID Title Journal Year
23270877 Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism

Mah, W, Deme, JC, Watkins, D, Fung, S, Janer, A, Shoubridge, EA, Rosenblatt, DS, Coulton, JW

Mol. Genet. Metab. 2013
21071249 Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism

Plesa, M, Kim, J, Paquette, SG, Gagnon, H, Ng-Thow-Hing, C, Gibbs, BF, Hancock, MA, Rosenblatt, DS, Coulton, JW

Mol. Genet. Metab. 2011
22832074 Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism

Deme, JC, Miousse, IR, Plesa, M, Kim, JC, Hancock, MA, Mah, W, Rosenblatt, DS, Coulton, JW

Mol. Genet. Metab. 2012
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