Beta-catenin migrates to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated β-catenin migrates to the nucleus where it functions as a coactivator of IRF3-dependent transcription (Yang P et al. 2010). Besides phosphorylation, other post-translational modifications of β-catenin including O-GlcNAc-glycosylation (Ha JR et al., 2014) or acetylation (reviewed by You H et al., 2022) may regulate stability, subcellular localization and function of β-catenin.

The mechanisms that control β-catenin localization are not fully elucidated. β-catenin transport to the nucleus is thought to occur in a NLS (nuclear localization signal)- and importin-independent manner through direct interaction with the nuclear pore complex (NPC) components. This has been shown to be the case for Wnt-signaling in mammalian cells (Yokoya F et al. 1999; Koike M et al. 2004). β-catenin may also 'piggy-back' into the nucleus in complex with other proteins such as FOXM1 (Zhang N et al., 2011 ) or BCL9 (Townsley FM et al., 2004).

Literature References
PubMed ID Title Journal Year
15173161 beta-Catenin shows an overlapping sequence requirement but distinct molecular interactions for its bidirectional passage through nuclear pores

Taniguchi, N, Imamoto, N, Koike, M, Furuta, M, Yokoya, F, Kose, S, Yoneda, Y

J. Biol. Chem. 2004
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H

Nat. Immunol. 2010
Orthologous Events
Cite Us!