Beta-catenin migrates to the nucleus

Stable Identifier
R-HSA-3134914
Type
Reaction [omitted]
Species
Homo sapiens
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Phosphorylated beta-catenin migrates to the nucleus where it functions as a coactivator of IRF3-dependent transcription (Yang P et al. 2010).

Beta-catenin transport to the nucleus is thought to occur in a NLS (nuclear localization signal)- and importin-independent manner through direct interaction with the nuclear pore complex (NPC) components. This has been shown to be the case for Wnt-signaling in mammalian cells (Yokoya F et al. 1999; Koike M et al. 2004; Sharma M et al. 2012)

Literature References
PubMed ID Title Journal Year
22110128 Specific armadillo repeat sequences facilitate ?-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62, Nup153, and RanBP2/Nup358

Sharma, M, Jamieson, C, Johnson, M, Molloy, MP, Henderson, BR

J. Biol. Chem. 2012
15173161 beta-Catenin shows an overlapping sequence requirement but distinct molecular interactions for its bidirectional passage through nuclear pores

Koike, M, Kose, S, Furuta, M, Taniguchi, N, Yokoya, F, Yoneda, Y, Imamoto, N

J. Biol. Chem. 2004
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Yang, P, An, H, Liu, X, Wen, M, Zheng, Y, Rui, Y, Cao, X

Nat. Immunol. 2010
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