Phosphorylation of beta-catenin at Ser552

Stable Identifier
R-HSA-3134904
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Hepatitis C Virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of beta-catenin at Ser552
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Beta-catenin undergoes phosphorylation at Ser552 in a Lrrfip1-dependent manner in pathogen-infected mouse macrophages (Yang P et al. 2010). Studies on human cells showed that the protein kinase Akt can phosphorylate beta-catenin at Ser552 upon treatment with various stimuli such as epidermal growth factor (EGF) or hepatitis C virus (HCV). However, it remains to be determined which kinase is involved in up-regulation of beta-catenin downstream of LRRFIP1 (Fang D et al. 2007; Bose SK et al. 2012). Phosphorylated beta-catenin translocates to the nucleus.
Literature References
PubMed ID Title Journal Year
23035229 Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes

Meyer, K, Ray, RB, Bose, SK, Ray, R, Di Bisceglie, AM

J. Virol. 2012
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H

Nat. Immunol. 2010
Participants
Input
Output
Participates
as an event of
Authored
Shamovsky, V  (2013-02-06)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
D'Eustachio, P  (2013-02-11)
Created
Shamovsky, V  (2013-02-13)
Cite Us!