Phosphorylation of beta-catenin at Ser552

Stable Identifier
Reaction [dissociation]
Homo sapiens
Related Species
Hepatitis C Virus
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Beta-catenin undergoes phosphorylation at Ser552 in a Lrrfip1-dependent manner in pathogen-infected mouse macrophages (Yang P et al. 2010). Studies on human cells showed that the protein kinase Akt can phosphorylate beta-catenin at Ser552 upon treatment with various stimuli such as epidermal growth factor (EGF) or hepatitis C virus (HCV). However, it remains to be determined which kinase is involved in up-regulation of beta-catenin downstream of LRRFIP1 (Fang D et al. 2007; Bose SK et al. 2012). Phosphorylated beta-catenin translocates to the nucleus.

Literature References
PubMed ID Title Journal Year
23035229 Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes

Meyer, K, Ray, RB, Bose, SK, Ray, R, Di Bisceglie, AM

J. Virol. 2012
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H

Nat. Immunol. 2010
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