Phosphorylation of beta-catenin at Ser552

Stable Identifier
R-HSA-3134904
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Hepatitis C Virus
Compartment
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Beta-catenin undergoes phosphorylation at Ser552 in a Lrrfip1-dependent manner in pathogen-infected mouse macrophages (Yang P et al. 2010). Studies on human cells showed that the protein kinase Akt can phosphorylate beta-catenin at Ser552 upon treatment with various stimuli such as epidermal growth factor (EGF) or hepatitis C virus (HCV). However, it remains to be determined which kinase is involved in up-regulation of beta-catenin downstream of LRRFIP1 (Fang D et al. 2007; Bose SK et al. 2012). Phosphorylated beta-catenin translocates to the nucleus.

Literature References
PubMed ID Title Journal Year
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Yang, P, An, H, Liu, X, Wen, M, Zheng, Y, Rui, Y, Cao, X

Nat. Immunol. 2010
23035229 Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes

Bose, SK, Meyer, K, Di Bisceglie, AM, Ray, RB, Ray, R

J. Virol. 2012
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