LRR FLII-interacting protein 1 associates with beta-catenin

Stable Identifier
R-HSA-3134901
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Hepatitis C Virus
Compartment
cytosol
ReviewStatus
5/5
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LRR FLII-interacting protein 1 associates with beta-catenin
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The cytosolic protein beta-catenin is known as a transcriptional cofactor in Wnt signaling pathway. Beta-catenin has been also implicated in LRRFIP1-mediated induction of type I IFN. Beta-catenin was shown to bind Lrrfip1 in L. monocytogenes-infected mouse macrophages but not in resting macrophages (Yang P et al 2010). The interaction of beta-catenin and LRRFIP1 was also reported for human proteins when they were co-expressed in human embryonic kidney 293T (HEK293T) cells followed by co-immunoprecipitation assay. The co-immunoprecipitation results were consistent with the GST-pulldown data (Lee YH and Stallcup MR 2006).
Literature References
PubMed ID Title Journal Year
20453844 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H

Nat. Immunol. 2010
16990252 Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription

Lee, YH, Stallcup, MR

Nucleic Acids Res. 2006
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Authored
Shamovsky, V  (2013-02-06)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
D'Eustachio, P  (2013-02-11)
Created
Shamovsky, V  (2013-02-13)
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