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LRR FLII-interacting protein 1 associates with beta-catenin
Stable Identifier
R-HSA-3134901
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Hepatitis C Virus
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)
LRR FLII-interacting protein 1 associates with beta-catenin (Homo sapiens)
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The cytosolic protein beta-catenin is known as a transcriptional cofactor in Wnt signaling pathway. Beta-catenin has been also implicated in LRRFIP1-mediated induction of type I IFN. Beta-catenin was shown to bind Lrrfip1 in L. monocytogenes-infected mouse macrophages but not in resting macrophages (Yang P et al 2010). The interaction of beta-catenin and LRRFIP1 was also reported for human proteins when they were co-expressed in human embryonic kidney 293T (HEK293T) cells followed by co-immunoprecipitation assay. The co-immunoprecipitation results were consistent with the GST-pulldown data (Lee YH and Stallcup MR 2006).
Literature References
PubMed ID
Title
Journal
Year
20453844
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
Wen, M
,
Rui, Y
,
Liu, X
,
Yang, P
,
Cao, X
,
Zheng, Y
,
An, H
Nat. Immunol.
2010
16990252
Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription
Lee, YH
,
Stallcup, MR
Nucleic Acids Res.
2006
Participants
Input
CTNNB1 [cytosol]
(Homo sapiens)
dsDNA:LRR FLII-interacting protein 1dimer [cytosol]
(Homo sapiens)
Output
dsDNA:LRRFIP1:beta-catenin [cytosol]
(Homo sapiens)
Participates
as an event of
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production (Homo sapiens)
Authored
Shamovsky, V (2013-02-06)
Reviewed
Wu, J (2013-05-22)
Jin, L (2013-05-22)
D'Eustachio, P (2013-02-11)
Created
Shamovsky, V (2013-02-13)
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