STING ubiquitination by TRIM32 or TRIM56

Stable Identifier
R-HSA-3134804
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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E3 ubiquitin-protein ligase TRIM32 and TRIM56 were shown to enhance type I IFN induction and cellular antiviral response by promoting K63-linked ubiquitination of STING.

Literature References
PubMed ID Title Journal Year
22745133 TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

Zhang, J, Hu, MM, Wang, YY, Shu, HB

J. Biol. Chem. 2012
21074459 The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

Tsuchida, T, Zou, J, Saitoh, T, Kumar, H, Abe, T, Matsuura, Y, Kawai, T, Akira, S

Immunity 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of STING:TRIM32/TRIM56 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created