STING was shown to undergo K63‑linked ubiquitination, which may facilitate its dimerization (Tsuchid T et al. 2010; Zhang J et al. 2012). The de‑ubiquitinating enzyme, severe acute respiratory syndrome coronavirus type 1 (SARS‑CoV-1) 1a‑encoded papain‑like protease (PLPro or nsp3), inhibits the ubiquitination of STING (Chen X et al. 2014).
Kao, CC, Li, P, Watts, T, Yi, G, Shu, C
Parvatiyar, K, Cheng, G, Niu, F, Qiu, W, Zhu, Y, Shaw, N, Ru, H, Liu, ZJ, Wang, Y, Ouyang, S, Song, X, Zhang, R, Li, Y, Jiang, Y
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