Reactome | VEGFA [platelet alpha granule lumen]

VEGFA [platelet alpha granule lumen]

Stable Identifier

R-HSA-3132764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Vascular endothelial growth factor A, VEGFA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P15692 VEGFA

Gene Names

VEGFA, VEGF

Chain

signal peptide:1-26, chain:27-232

Reference Genes

BioGPS Gene:7422 VEGFA

COSMIC (genes):VEGFA VEGFA

CTD Gene:7422 VEGFA

dbSNP Gene:7422 VEGFA

ENSEMBL:ENSG00000112715 VEGFA

HGNC:12680 VEGFA

KEGG Gene (Homo sapiens):7422 VEGFA

Monarch:7422 VEGFA

NCBI Gene:7422 VEGFA

OMIM:192240 VEGFA

UCSC:P15692 VEGFA

Reference Transcript

Other Identifiers

11725370_s_at

11725371_s_at

11725372_x_at

11738414_a_at

11741964_s_at

11741965_x_at

11750313_x_at

11755745_x_at

1953_at

210512_s_at

210513_s_at

211527_x_at

212171_x_at

2908180

2908181

2908182

2908186

2908189

2908192

2908194

2908196

2908197

2908200

2908202

2908203

2908204

2908205

2908207

36100_at

36101_s_at

73146_at

7422

8119898

A_14_P121725

A_14_P138589

A_23_P81805

A_24_P12401

A_24_P179400

GE54171

GE767555

GO:0000003

GO:0000122

GO:0000902

GO:0001525

GO:0001541

GO:0001569

GO:0001570

GO:0001666

GO:0001701

GO:0001822

GO:0001934

GO:0001938

GO:0001968

GO:0002040

GO:0002042

GO:0002052

GO:0002053

GO:0002092

GO:0002376

GO:0002575

GO:0002576

GO:0002687

GO:0003007

GO:0003013

GO:0003151

GO:0003169

GO:0003674

GO:0005125

GO:0005161

GO:0005172

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005912

GO:0006259

GO:0006357

GO:0006464

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007275

GO:0007399

GO:0007498

GO:0007595

GO:0008083

GO:0008150

GO:0008201

GO:0008219

GO:0008283

GO:0008284

GO:0008360

GO:0009058

GO:0009790

GO:0009986

GO:0010595

GO:0010628

GO:0010629

GO:0010749

GO:0014068

GO:0016020

GO:0016192

GO:0019221

GO:0021700

GO:0022607

GO:0030141

GO:0030154

GO:0030224

GO:0030225

GO:0030324

GO:0030335

GO:0030855

GO:0031012

GO:0031077

GO:0031093

GO:0031334

GO:0031410

GO:0031954

GO:0032147

GO:0032793

GO:0033138

GO:0034330

GO:0034641

GO:0035148

GO:0035767

GO:0035924

GO:0036303

GO:0036324

GO:0038033

GO:0038084

GO:0038089

GO:0038091

GO:0038190

GO:0038191

GO:0040007

GO:0040011

GO:0042056

GO:0042327

GO:0042462

GO:0042592

GO:0042802

GO:0042803

GO:0043066

GO:0043117

GO:0043129

GO:0043154

GO:0043167

GO:0043183

GO:0043184

GO:0043226

GO:0043406

GO:0043410

GO:0043536

GO:0045766

GO:0045785

GO:0045944

GO:0048010

GO:0048018

GO:0048469

GO:0048593

GO:0048646

GO:0048739

GO:0048754

GO:0048842

GO:0048844

GO:0048856

GO:0048870

GO:0050679

GO:0050731

GO:0050840

GO:0050918

GO:0050927

GO:0050930

GO:0051272

GO:0051276

GO:0051301

GO:0051781

GO:0051894

GO:0051897

GO:0060319

GO:0060749

GO:0060754

GO:0060948

GO:0060982

GO:0061042

GO:0061418

GO:0061419

GO:0065003

GO:0070374

GO:0071456

GO:0071542

GO:0071679

GO:0090037

GO:0090050

GO:0090190

GO:0090259

GO:0097475

GO:0097533

GO:0120162

GO:1900086

GO:1900745

GO:1901165

GO:1901727

GO:1902336

GO:1902966

GO:1903141

GO:1903392

GO:1903572

GO:1903589

GO:1903672

GO:1905278

GO:1905604

GO:2000048

GO:2000573

HMNXSV003013113

Hs.73793.2.S2_3p_a_at

ILMN_1693060

ILMN_1803882

ILMN_2375879

M27281_at

PH_hs_0004213

TC06002799.hg

g340300_3p_a_at

g3719220_3p_a_at

g5901560_3p_a_at

g5901560_3p_s_at

Participates

as a member of

VEGFs [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

VEGFA [extracellular region]

Inferred To

vegfa [platelet alpha granule lumen] (Xenopus tropicalis)

vegfab [platelet alpha granule lumen] (Danio rerio)

VEGFA [platelet alpha granule lumen] (Canis familiaris)

VEGFA [platelet alpha granule lumen] (Gallus gallus)

Vegfa [platelet alpha granule lumen] (Mus musculus)

Vegfa [platelet alpha granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001303939.1, NP_001191313.1, NP_001273973.1, NP_001020538.2, NP_001020537.2, NP_001165093.1, NP_001020539.2, NP_001165095.1, NP_001165101.1, NP_001165094.1, NP_001165096.1, NP_003367.4, NP_001165100.1, NP_001165097.1, NP_001020541.2, NP_001191314.1, NP_001028928.1, NP_001020540.2, NP_001165098.1, NP_001165099.1

OpenTargets

ENSG00000112715

ZINC - Substances

VEGFA_HUMAN

ZINC - Biogenic

VEGFA_HUMAN

ZINC target

P15692

PRO

P15692

GlyGen

P15692

PDB

1VPF, 3V2A, 7LL8, 1KMX, 1CZ8, 5HHD, 3S1B, 2FJH, 5FV2, 3QTK, 6D3O, 4DEQ, 2QR0, 6T9D, 2FJG, 1MJV, 2VPF, 7LL9, 5FV1, 5HHC, 1FLT, 1BJ1, 5T89, 3BDY, 1KAT, 4QAF, 3P9W, 5O4E, 4ZFF, 5DN2, 1MKK, 4GLS, 4GLN, 4KZN, 3S1K, 6V7K, 1VPP, 1VGH, 1TZI, 6BFT, 1TZH, 2VGH, 1MKG, 1QTY, 4WPB

ZINC - Metabolites

VEGFA_HUMAN

GeneCards

P15692

HPA

ENSG00000112715-VEGFA

Ensembl

ENST00000523125, ENSG00000112715, ENSP00000429008, ENST00000523950, ENST00000523873, ENSP00000409911, ENSP00000361148, ENST00000457104, ENST00000518689, ENST00000520948, ENSP00000430829, ENSP00000429643, ENST00000518824, ENSP00000430479, ENST00000372077, ENSP00000430002, ENSP00000428321

Pharos - Targets

P15692

Orphanet

25029

ZINC - Predictions - Purchasable

VEGFA_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35968 KDR	4	VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.86	6
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.761	4
UniProt:P15692 VEGFA	2	VEGFA [platelet alpha granule lumen] (R-HSA-3132764) VEGFA [extracellular region] (R-HSA-2975974)	0.719	10
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.697	4