Reactome | VEGFA [platelet alpha granule lumen]

VEGFA [platelet alpha granule lumen]

Stable Identifier

R-HSA-3132764

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Vascular endothelial growth factor A, VEGFA_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11731620	New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation Prats, H, Bresson, D, Créancier, L, Bornes, S, Huez, I	Mol Endocrinol	2001
11563986	A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon Jaffe, RB, Tee, MK	Biochem J	2001

External Reference Information

External Reference

UniProt:P15692 VEGFA

Gene Names

VEGFA, VEGF

Chain

chain:1-395, chain:1-, chain:-395

Reference Genes

BioGPS Gene:7422 VEGFA

COSMIC (genes):VEGFA VEGFA

CTD Gene:7422 VEGFA

dbSNP Gene:7422 VEGFA

ENSEMBL:ENSG00000112715 VEGFA

HGNC:12680 VEGFA

KEGG:hsa:7422 VEGFA

Monarch:7422 VEGFA

NCBI Gene:7422 VEGFA

OMIM:192240 VEGFA

UCSC:P15692 VEGFA

Reference Transcript

Participates

as a member of

VEGFs [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

VEGFA [extracellular region]

Inferred To

vegfaa [platelet alpha granule lumen] (Danio rerio)

vegfa [platelet alpha granule lumen] (Xenopus tropicalis)

VEGFA [platelet alpha granule lumen] (Bos taurus)

VEGFA [platelet alpha granule lumen] (Canis familiaris)

VEGFA [platelet alpha granule lumen] (Gallus gallus)

VEGFA [platelet alpha granule lumen] (Sus scrofa)

Vegfa [platelet alpha granule lumen] (Mus musculus)

Vegfa [platelet alpha granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001165094.1, NP_001165095.1, NP_001165093.1, NP_001020541.2, NP_001028928.1, NP_001165101.1, NP_001020540.2, NP_001165100.1, NP_001273973.1, NP_001020539.2, NP_001165099.1, NP_001165098.1, NP_001020538.2, NP_001165097.1, NP_001020537.2, NP_001165096.1, NP_001191313.1, NP_001191314.1, NP_001303939.1, NP_003367.4

OpenTargets

ENSG00000112715

ENSEMBL

ENSG00000112715, ENST00000518824, ENSP00000429643, ENST00000520948, ENSP00000429008, ENST00000324450, ENSP00000389864, ENST00000523125, ENSP00000361134, ENST00000372055, ENST00000457104, ENST00000372077, ENSP00000409911, ENST00000372064, ENSP00000361137, ENSP00000430479, ENSP00000500082, ENSP00000428321, ENSP00000388663, ENST00000523873, ENST00000523950, ENST00000672860, ENST00000372067, ENSP00000430829, ENSP00000421561, ENST00000413642, ENST00000482630, ENSP00000361125, ENST00000417285, ENSP00000317598, ENSP00000361148, ENST00000518689, ENSP00000430002

ZINC - Substances

VEGFA_HUMAN

ZINC - Biogenic

VEGFA_HUMAN

ZINC target

P15692

PRO

P15692

GlyGen

P15692

PDB

5HHC, 8UWZ, 1VPF, 2FJG, 2FJH, 6ZCD, 1VPP, 5O4E, 6V7K, 4GLN, 4GLS, 1TZI, 7LL9, 7KEZ, 3S1B, 1QTY, 1FLT, 3S1K, 6ZBR, 4QAF, 1VGH, 3V2A, 6Z13, 5FV2, 6BFT, 4ZFF, 1MKK, 1MKG, 5HHD, 1KAT, 7KF1, 3QTK, 9KKU, 3P9W, 1MJV, 3BDY, 2VGH, 6D3O, 4WPB, 1TZH, 2VPF, 6Z3F, 7LL8, 6ZFL, 1CZ8, 4DEQ, 1KMX, 2QR0, 6T9D, 4KZN, 5T89, 5FV1, 5DN2, 9JU1, 7KF0, 1BJ1

ZINC - Metabolites

VEGFA_HUMAN

GeneCards

VEGFA

HPA

ENSG00000112715-VEGFA

Pharos - Targets

P15692

ZINC - Predictions - Purchasable

VEGFA_HUMAN

HMDB Protein

HMDBP02130

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.819	5
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.808	5
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.77	5
UniProt:P15692 VEGFA	2	VEGFA [extracellular region] (R-HSA-2975974) VEGFA [platelet alpha granule lumen] (R-HSA-3132764)	0.719	10
UniProt:P49765 VEGFB	2	VEGFB [platelet alpha granule lumen] (R-HSA-3132756) VEGFB [extracellular region] (R-HSA-2975973)	0.483	2

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