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K48polyUb-RNF125 [cytosol]
Stable Identifier
R-HSA-3080560
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
polyubiquitin-conjugated E3 ubiquitin-protein ligase RNF125
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
RNF125 mediated ubiquitination of DDX58, IFIH1 and MAVS (Homo sapiens)
K48polyUb-RNF125 [cytosol] (Homo sapiens)
RNF125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol] (Homo sapiens)
K48polyUb-RNF125 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96EQ8 RNF125
Gene Names
RNF125
Chain
initiator methionine:, chain:2-232
Reference Genes
BioGPS Gene:54941 RNF125
COSMIC (genes):RNF125 RNF125
CTD Gene:54941 RNF125
dbSNP Gene:54941 RNF125
ENSEMBL:ENSG00000101695 RNF125
ENSEMBL_homo_sapiens_GENE:ENSG00000101695.9 RNF125
HGNC:21150 RNF125
KEGG Gene (Homo sapiens):54941 RNF125
Monarch:54941 RNF125
NCBI Gene:54941 RNF125
OMIM:610432 RNF125
UCSC:Q96EQ8 RNF125
Reference Transcript
RefSeq:NM_017831.3 RNF125
Other Identifiers
11730477_at
11730478_at
16851801
207735_PM_at
207735_at
235199_PM_at
235199_at
3680640
3783725
3783731
3783732
3783735
3783736
3783739
3783741
3783742
3783744
3783746
54941
8020806
83118_at
A_23_P101141
A_33_P3257993
GO:0000139
GO:0000209
GO:0002039
GO:0002250
GO:0002376
GO:0003824
GO:0005515
GO:0005783
GO:0005794
GO:0006511
GO:0008270
GO:0016020
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0031624
GO:0032480
GO:0034098
GO:0036211
GO:0039536
GO:0043226
GO:0043231
GO:0046872
GO:0061630
GO:0098542
GO:0140096
GO:1990830
HMNXSV003048986
Hs.276860.0.S1_3p_at
Hs.276860.0.S1_3p_x_at
ILMN_1747192
PH_hs_0014229
PH_hs_0031817
TC18000132.hg
g8923428_3p_at
g8923428_3p_x_at
Participates
as a component of
RNF125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol] (Homo sapiens)
Other forms of this molecule
RNF125 [cytosol]
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_060301.2
OpenTargets
ENSG00000101695
IntEnz
2.3.2.27
HPA
ENSG00000101695-RNF125
GeneCards
Q96EQ8
Ensembl
ENSG00000101695
,
ENST00000217740
,
ENSP00000217740
PRO
Q96EQ8
Pharos - Targets
Q96EQ8
Orphanet
24862
PDB
5DKA
,
8GCB
,
8GBQ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96LR5 UBE2E2
1
UBE2E2 [cytosol]
(R-HSA-947626)
0.674
5
UniProt:O95786 RIGI
4
PolyUb-DDX58 [cytosol]
(R-HSA-6782770)
K48polyUb-DDX58 [cytosol]
(R-HSA-3080568)
K63polyUb-DDX58 [cytosol]
(R-HSA-918191)
DDX58 [cytosol]
(R-HSA-168917)
0.591
4
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [cytosol]
(R-HSA-1181251)
0.591
3
UniProt:O95786-1 RIGI
0.576
5
UniProt:P68036 UBE2L3
4
Ub-C86-UBE2L3 [nucleoplasm]
(R-HSA-8864226)
UBE2L3 [nucleoplasm]
(R-HSA-8852056)
UBE2L3 [cytosol]
(R-HSA-947631)
Ub-C86-UBE2L3 [cytosol]
(R-HSA-8864201)
0.488
2
UniProt:O14933 UBE2L6
2
UBE2L6 [cytosol]
(R-HSA-936014)
UBE2L6 [nucleoplasm]
(R-HSA-5653666)
0.488
2
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