Reactome | PEX19 [cytosol]

PEX19 [cytosol]

Stable Identifier

R-HSA-3009036

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Peroxisomal biogenesis factor 19, PEX19_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P23284 PPIB

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External Reference Information

External Reference

UniProt:P40855 PEX19

Gene Names

PEX19, HK33, PXF, OK/SW-cl.22

Chain

initiator methionine:, chain:2-296, propeptide:297-299

Reference Genes

BioGPS Gene:5824 PEX19

COSMIC (genes):PEX19 PEX19

CTD Gene:5824 PEX19

dbSNP Gene:5824 PEX19

ENSEMBL:ENSG00000162735 PEX19

ENSEMBL_homo_sapiens_GENE:ENSG00000162735.19 PEX19

HGNC:9713 PEX19

KEGG Gene (Homo sapiens):5824 PEX19

Monarch:5824 PEX19

NCBI Gene:5824 PEX19

OMIM:600279 PEX19

UCSC:P40855 PEX19

Reference Transcript

Other Identifiers

11732123_a_at

11732124_a_at

11733124_a_at

11733125_a_at

16695321

201706_PM_s_at

201706_s_at

201707_PM_at

201707_at

2440118

2440119

2440120

2440121

2440122

2440123

2440124

2440125

2440126

2440127

2440129

2440131

2440132

2440133

2440134

2440135

2440136

2440139

40471_at

5824

7921571

A_23_P160188

A_24_P19752

GE80865

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005777

GO:0005778

GO:0005829

GO:0005886

GO:0006457

GO:0006625

GO:0006886

GO:0007031

GO:0016020

GO:0016557

GO:0016559

GO:0031526

GO:0032991

GO:0033328

GO:0036105

GO:0043226

GO:0045046

GO:0050821

GO:0051117

GO:0061077

GO:0072663

GO:0140104

GO:0140597

GO:1900131

HMNXSV003023092

ILMN_1658759

PH_hs_0025832

TC01005889.hg

TC01006278.hg

X75535_at

g12653448_3p_a_at

g4506338_3p_at

Participates

as an output of

as an input of

as a component of

Inferred To

Pex19 [cytosol] (Drosophila melanogaster)

Pex19 [cytosol] (Mus musculus)

Pex19 [cytosol] (Rattus norvegicus)

prx-19 [cytosol] (Caenorhabditis elegans)

pex19 [cytosol] (Danio rerio)

pex19 [cytosol] (Dictyostelium discoideum)

pex19 [cytosol] (Xenopus tropicalis)

PEX19 [cytosol] (Bos taurus)

PEX19 [cytosol] (Canis familiaris)

PEX19 [cytosol] (Gallus gallus)

PEX19 [cytosol] (Saccharomyces cerevisiae)

PEX19 [cytosol] (Schizosaccharomyces pombe)

PEX19 [cytosol] (Sus scrofa)

Modified Residues

Name

S-farnesyl-L-cysteine at 296

Coordinate

296

PsiMod Name

S-farnesyl-L-cysteine [MOD:00111]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.

Cross References

RefSeq

NP_001180573.1, NP_002848.1

OpenTargets

ENSG00000162735

GeneCards

P40855

HPA

ENSG00000162735-PEX19

Ensembl

ENST00000368072, ENSP00000434633, ENSP00000357051, ENST00000472750, ENSG00000162735

PRO

P40855

Pharos - Targets

P40855

Orphanet

16643

PDB

3MK4, 3AJB, 5LNF, 2WL8, 2W85

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56589 PEX3	2	PEX3 [cytosol] (R-HSA-9603792) PEX3 [peroxisomal membrane] (R-HSA-382608)	0.982	60
UniProt:O96011 PEX11B	2	PEX11B [peroxisomal membrane] (R-HSA-9625561) PEX11B [cytosol] (R-HSA-9625562)	0.955	31
UniProt:O75381 PEX14	2	PEX14 [cytosol] (R-HSA-9603806) PEX14 [peroxisomal membrane] (R-HSA-9033101)	0.952	31
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.949	29
UniProt:Q9NR77 PXMP2	2	PXMP2 [cytosol] (R-HSA-9603794) PXMP2 [peroxisomal membrane] (R-HSA-8953432)	0.77	5
UniProt:Q9NPF7 IL23A	2	IL23A [endoplasmic reticulum lumen] (R-HSA-8950224) IL23A [extracellular region] (R-HSA-447245)	0.718	6
UniProt:P23284 PPIB	2	PPIB [endoplasmic reticulum lumen] (R-HSA-1980262) PPIB [cytosol] (R-HSA-9728770)	0.718	6
UniProt:O43808 SLC25A17	2	SLC25A17 [cytosol] (R-HSA-9603781) SLC25A17 [peroxisomal membrane] (R-HSA-389642)	0.713	4
UniProt:Q92968 PEX13	2	PEX13 [cytosol] (R-HSA-9603795) PEX13 [peroxisomal membrane] (R-HSA-452790)	0.709	12
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.683	9
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.682	4
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.643	4
UniProt:P28328 PEX2	2	PEX2 [cytosol] (R-HSA-9625570) PEX2 [peroxisomal membrane] (R-HSA-8953913)	0.59	4
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:Q3E842 YM122			0.556	3
UniProt:Q9UIG4 PS1C2			0.556	5
UniProt:P01574 IFNB1	1	IFNB1 [extracellular region] (R-HSA-877351)	0.556	3
UniProt:Q8N9F0 NAT8L	1	NAT8L [mitochondrial matrix] (R-HSA-8954477)	0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:Q6P1Q0 LTMD1			0.527	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.527	4
UniProt:P62341 SELT			0.527	2
UniProt:Q8N2A8 PLD6	2	PLD6 [endoplasmic reticulum membrane] (R-HSA-1498811) PLD6 [mitochondrial outer membrane] (R-HSA-5601898)	0.527	2
UniProt:Q96K12 FAR2	1	FAR2 [peroxisomal membrane] (R-HSA-390430)	0.527	4
UniProt:Q8TBP5 F174A			0.527	4
UniProt:Q10469 MGAT2	6	MGAT2 C339* [Golgi membrane] (R-HSA-4839829) MGAT2 N318D [Golgi membrane] (R-HSA-4839827) MGAT2 S290F [Golgi membrane] (R-HSA-4839804) MGAT2 H262R [Golgi membrane] (R-HSA-4839821) MGAT2 K237N [Golgi membrane] (R-HSA-4839784) MGAT2 [Golgi membrane] (R-HSA-975830)	0.527	4
UniProt:Q8IW92 GLB1L2	1	GLB1L2 [lysosomal lumen] (R-HSA-9840308)	0.527	2
UniProt:Q8IZT6 ASPM			0.527	4
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q9ULX7 CA14	1	CA14 [plasma membrane] (R-HSA-1237018)	0.527	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2
UniProt:O75063 XYLK			0.527	2
UniProt:Q86YD1 PTOV1			0.527	3
UniProt:Q9ULV0 MYO5B	1	MYO5B [cytoplasmic vesicle membrane] (R-HSA-2028712)	0.527	2
UniProt:P21709 EPHA1	2	p-Y599,Y605-EPHA1 [plasma membrane] (R-HSA-3928336) EPHA1 [plasma membrane] (R-HSA-211415)	0.527	3
UniProt:Q8WUY8 NAT14			0.527	4
UniProt:Q9BW72 HIGD2A	1	HIGD2A [mitochondrial inner membrane] (R-HSA-9865687)	0.527	3
UniProt:Q9BQ75 CMS1			0.527	2
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	4
UniProt:O94923 GLCE	1	GLCE [Golgi membrane] (R-HSA-2024106)	0.527	3
UniProt:Q9NQX4 MYO5C			0.527	3
UniProt:Q10471 GALNT2	2	GALNT2(1-571) [endoplasmic reticulum membrane] (R-HSA-8849322) GALNT2(1-571) [Golgi membrane] (R-HSA-913618)	0.527	4
UniProt:P20138 CD33	3	CD33 [tertiary granule membrane] (R-HSA-6800959) CD33 [plasma membrane] (R-HSA-197719) CD33 [specific granule membrane] (R-HSA-6799615)	0.527	2
UniProt:Q6IPU0 CENPP	2	CENPP [nucleoplasm] (R-HSA-606341) CENPP [cytosol] (R-HSA-375299)	0.527	3
UniProt:Q96NR8 RDH12	6	RDH12 [photoreceptor inner segment membrane] (R-HSA-2464787) RDH12 Ala269Glyfs2 [photoreceptor inner segment membrane] (R-HSA-2471748) RDH12 H151N [photoreceptor inner segment membrane] (R-HSA-2471751) RDH12 Y226C [photoreceptor inner segment membrane] (R-HSA-2471697) RDH12 Q189 [photoreceptor inner segment membrane] (R-HSA-2471667) RDH12 A126V [photoreceptor inner segment membrane] (R-HSA-2471753)	0.527	2
UniProt:Q6P1S2 CC033			0.527	3
UniProt:Q16394 EXT1	6	EXT1 R339L [Golgi membrane] (R-HSA-3730912) EXT1 L490Rfs9 [Golgi membrane] (R-HSA-3730975) EXT1 R340C [Golgi membrane] (R-HSA-3730974) EXT1 G339D [Golgi membrane] (R-HSA-3730910) EXT1 G198Afs54 [Golgi membrane] (R-HSA-3730971) EXT1 [Golgi membrane] (R-HSA-2022897)	0.527	2
UniProt:Q96L58 B3GALT6	11	B3GALT6 [Golgi membrane] (R-HSA-913714) B3GALT6 G217S [Golgi membrane] (R-HSA-4420322) B3GALT6 S65G [Golgi membrane] (R-HSA-4420368) B3GALT6 M1? [Golgi membrane] (R-HSA-4420341) B3GALT6 R197Afs81 [Golgi membrane] (R-HSA-4420356) B3GALT6 R232C [Golgi membrane] (R-HSA-4420361) B3GALT6 D156N [Golgi membrane] (R-HSA-4420367) B3GALT6 C300S [Golgi membrane] (R-HSA-4420366) B3GALT6 D118Afs160 [Golgi membrane] (R-HSA-4420334) B3GALT6 D207H [Golgi membrane] (R-HSA-4420350) B3GALT6 P67L [Golgi membrane] (R-HSA-4420348)	0.527	2
UniProt:Q9Y2C4 EXOG			0.527	4
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.527	3
UniProt:Q9NXS2 QPCTL			0.527	2
UniProt:O94832 MYO1D			0.527	4
UniProt:Q9NS84 CHST7	1	CHST7 [Golgi membrane] (R-HSA-1971545)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	5
UniProt:Q8NBX0 SCCPDH	2	SCCPDH [extracellular region] (R-HSA-8862997) SCCPDH [platelet alpha granule lumen] (R-HSA-8862982)	0.527	4
UniProt:Q969V5 MUL1	2	PolyUb-MUL1 [mitochondrial outer membrane] (R-HSA-6783184) MUL1 [mitochondrial outer membrane] (R-HSA-2993772)	0.527	4
UniProt:Q9H741 SPRNG			0.527	2
UniProt:Q8NHP6 MOSPD2	3	MOSPD2 [endosome membrane] (R-HSA-9715095) MOSPD2 [plasma membrane] (R-HSA-6806308) MOSPD2 [specific granule membrane] (R-HSA-6799635)	0.527	4
UniProt:Q9NVH0 EXD2			0.527	4
UniProt:P08574 CYC1	3	CYC1(1-325) [mitochondrial intermembrane space] (R-HSA-1267962) CYC1(1-325) [cytosol] (R-HSA-1267995) CYC1 [mitochondrial inner membrane] (R-HSA-164277)	0.527	4
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.527	2
UniProt:Q7LGA3 HS2ST1	1	HS2ST1 [Golgi membrane] (R-HSA-2076393)	0.527	3
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.527	4
UniProt:Q9NQE9 HINT3			0.527	3
UniProt:Q86X52 CHSY1	5	CHSY1 P539R [Golgi membrane] (R-HSA-3636862) CHSY1 E33Sfs2 [Golgi membrane] (R-HSA-3636864) CHSY1 Q69 [Golgi membrane] (R-HSA-3636838) CHSY1 G19_L28del [Golgi membrane] (R-HSA-3636823) CHSY1 [Golgi membrane] (R-HSA-1971431)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4

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