Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
NRP1 [plasma membrane]
Stable Identifier
R-HSA-3008773
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuropilin-1, NRP1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P21333%20FLNA
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
CHL1 interactions (Homo sapiens)
CHL1 interacts with NRP1 (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
Signal transduction by L1 (Homo sapiens)
L1 binds NRP1 (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
ROBO1 binds NRP1 (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
Neurophilin interactions with VEGF and VEGFR (Homo sapiens)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)
NRP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14786 NRP1
Gene Names
NRP1, NRP, VEGF165R
Chain
signal peptide:1-21, chain:22-923
Reference Genes
BioGPS Gene:8829 NRP1
COSMIC (genes):NRP1 NRP1
CTD Gene:8829 NRP1
dbSNP Gene:8829 NRP1
ENSEMBL:ENSG00000099250 NRP1
ENSEMBL_homo_sapiens_GENE:ENSG00000099250.18 NRP1
HGNC:8004 NRP1
KEGG Gene (Homo sapiens):8829 NRP1
Monarch:8829 NRP1
NCBI Gene:8829 NRP1
OMIM:602069 NRP1
UCSC:O14786 NRP1
Reference Transcript
RefSeq:NM_001024629.2 NRP1
RefSeq:NM_003873.5 NRP1
RefSeq:NM_001024628.2 NRP1
RefSeq:NM_001330068.1 NRP1
Other Identifiers
11728214_a_at
11728215_a_at
11750657_a_at
11757751_s_at
16713187
210510_PM_s_at
210510_s_at
212298_PM_at
212298_at
3284301
3284303
3284304
3284305
3284307
3284309
3284310
3284317
3284324
3284334
3284341
3284346
3284349
3284351
3284368
3284370
3284373
3284374
3284377
3284411
3284414
3284415
3284416
3284418
36836_at
46695_at
7932985
8829
A_23_P86390
A_24_P928052
A_32_P120330
GE535872
GE56542
GE81331
GO:0001525
GO:0001569
GO:0001570
GO:0001755
GO:0001764
GO:0001938
GO:0002040
GO:0002042
GO:0002116
GO:0003148
GO:0003824
GO:0005021
GO:0005096
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005829
GO:0005856
GO:0005883
GO:0005886
GO:0005925
GO:0006930
GO:0007010
GO:0007155
GO:0007165
GO:0007229
GO:0007267
GO:0007399
GO:0007411
GO:0007413
GO:0007507
GO:0008045
GO:0008201
GO:0009611
GO:0009887
GO:0010595
GO:0012501
GO:0014911
GO:0015026
GO:0016020
GO:0016192
GO:0016358
GO:0016740
GO:0017154
GO:0019838
GO:0019901
GO:0019955
GO:0021612
GO:0021636
GO:0021637
GO:0021649
GO:0021785
GO:0021828
GO:0023052
GO:0030154
GO:0030424
GO:0030517
GO:0030947
GO:0031290
GO:0031410
GO:0031966
GO:0032489
GO:0034330
GO:0035729
GO:0035767
GO:0035924
GO:0036211
GO:0036486
GO:0038084
GO:0038085
GO:0038189
GO:0038190
GO:0042327
GO:0043005
GO:0043226
GO:0043235
GO:0043524
GO:0043534
GO:0043542
GO:0045211
GO:0045766
GO:0046718
GO:0046872
GO:0048008
GO:0048010
GO:0048012
GO:0048485
GO:0048666
GO:0048675
GO:0048841
GO:0048842
GO:0048843
GO:0048844
GO:0048846
GO:0048856
GO:0048870
GO:0050731
GO:0050918
GO:0051491
GO:0051496
GO:0051894
GO:0060089
GO:0060301
GO:0060385
GO:0060627
GO:0060666
GO:0060978
GO:0060982
GO:0061298
GO:0061299
GO:0061441
GO:0061549
GO:0061551
GO:0070374
GO:0071526
GO:0071679
GO:0090050
GO:0097102
GO:0097374
GO:0097443
GO:0097475
GO:0097490
GO:0097491
GO:0098772
GO:0098978
GO:0099173
GO:0140096
GO:0150018
GO:0150020
GO:1900026
GO:1901166
GO:1902946
GO:1903375
GO:1904835
GO:1905040
GO:2001237
HMNXSV003025999
Hs.69285.2.S2_3p_at
Hs.69285.2.S2_3p_x_at
ILMN_1699574
ILMN_1742547
PH_hs_0022842
TC10001166.hg
g7271464_3p_a_at
Participates
as a component of
L1:NRP1 [plasma membrane] (Homo sapiens)
CHL1:NRP1 [plasma membrane] (Homo sapiens)
ROBO1:NRP1 [plasma membrane] (Homo sapiens)
NRP1:VEGFR2 dimer [plasma membrane] (Homo sapiens)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Homo sapiens)
Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's (S522,S518,T509,T514) [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
as an input of
L1 binds NRP1 (Homo sapiens)
CHL1 interacts with NRP1 (Homo sapiens)
ROBO1 binds NRP1 (Homo sapiens)
NRP-1 forms a ternary complex with VEGF165 and VEGFR1 (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
This entity regulates
Positively
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
(Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
(Homo sapiens)
Inferred To
NRP1 [plasma membrane]
(Bos taurus)
NRP1 [plasma membrane]
(Canis familiaris)
NRP1 [plasma membrane]
(Danio rerio)
NRP1 [plasma membrane]
(Gallus gallus)
NRP1 [plasma membrane]
(Rattus norvegicus)
NRP1 [plasma membrane]
(Sus scrofa)
NRP1 [plasma membrane]
(Xenopus tropicalis)
Nrp1 [plasma membrane]
(Mus musculus)
Ghost homologue of NRP1 [plasma membrane]
(Caenorhabditis elegans)
Ghost homologue of NRP1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001019800.1
,
NP_001019799.1
,
NP_003864.4
,
NP_001316997.1
Guide to Pharmacology - Targets
2998
OpenTargets
ENSG00000099250
ZINC - Substances
NRP1_HUMAN
ZINC target
O14786
PRO
O14786
PDB
5JGI
,
4DEQ
,
7JJC
,
5J1X
,
6TKK
,
2QQI
,
6FMC
,
5JHK
,
6FMF
,
5C7G
,
5JGQ
,
2QQM
,
7O1N
,
4RN5
,
5IYY
,
5L73
,
8PFE
,
3I97
,
1KEX
,
5IJR
,
2QQN
,
7P5U
GeneCards
O14786
HPA
ENSG00000099250-NRP1
Ensembl
ENST00000374867
,
ENSP00000265371
,
ENST00000374821
,
ENSP00000364001
,
ENSP00000363955
,
ENSG00000099250
,
ENSP00000363954
,
ENST00000374822
,
ENST00000265371
Pharos - Targets
O14786
ZINC - Predictions - Purchasable
NRP1_HUMAN
Orphanet
24768
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15692 VEGFA
2
VEGFA [platelet alpha granule lumen]
(R-HSA-3132764)
VEGFA [extracellular region]
(R-HSA-2975974)
0.697
4
UniProt:P19784 CSNK2A2
2
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
CSNK2A2 [cytosol]
(R-HSA-201721)
0.643
3
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
0.639
9
UniProt:P35968 KDR
4
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.589
2
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.558
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text