Reactome | RBPJ [nucleoplasm]

RBPJ [nucleoplasm]

Stable Identifier

R-HSA-3008668

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Recombining binding protein suppressor of hairless, SUH_HUMAN, CBF1

Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1

Expand all

External Reference Information

External Reference

UniProt:Q06330 RBPJ

Gene Names

RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH

Chain

chain:1-500

Reference Genes

BioGPS Gene:3516 RBPJ

COSMIC (genes):RBPJ RBPJ

CTD Gene:3516 RBPJ

dbSNP Gene:3516 RBPJ

ENSEMBL:ENSG00000168214 RBPJ

ENSEMBL_homo_sapiens_GENE:ENSG00000168214.22 RBPJ

HGNC:5724 RBPJ

KEGG Gene (Homo sapiens):3516 RBPJ

Monarch:3516 RBPJ

NCBI Gene:3516 RBPJ

OMIM:147183 RBPJ

UCSC:Q06330 RBPJ

Reference Transcript

Other Identifiers

11739392_a_at

11739393_s_at

11757737_s_at

11762366_s_at

16965642

207785_3p_s_at

207785_PM_s_at

207785_s_at

211974_3p_x_at

211974_PM_x_at

211974_x_at

2722201

2722202

2722204

2722205

2722206

2722207

2722208

2722209

2722210

2722211

2722220

2722228

2722235

2722237

2722239

2722240

2722241

2722242

2722244

2722245

2722246

2722247

2722248

2722251

2722254

2722255

2722256

2722258

2722260

2722261

2722262

2722263

2722264

2722265

2722266

3206395

3516

40818_at

65465_at

8094460

A_23_P29994

GE61651

GE62818

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0001525

GO:0001756

GO:0001837

GO:0001974

GO:0002193

GO:0002376

GO:0002437

GO:0003139

GO:0003151

GO:0003157

GO:0003160

GO:0003176

GO:0003177

GO:0003198

GO:0003214

GO:0003222

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0006091

GO:0006351

GO:0006355

GO:0006357

GO:0006954

GO:0006959

GO:0007155

GO:0007219

GO:0007221

GO:0007507

GO:0008283

GO:0009912

GO:0009957

GO:0010468

GO:0010628

GO:0017053

GO:0021983

GO:0022414

GO:0023052

GO:0030097

GO:0030154

GO:0030182

GO:0030183

GO:0030216

GO:0030279

GO:0030513

GO:0035019

GO:0035912

GO:0036302

GO:0042742

GO:0043011

GO:0043226

GO:0043467

GO:0043565

GO:0045165

GO:0045596

GO:0045892

GO:0045944

GO:0048505

GO:0048733

GO:0048820

GO:0048844

GO:0048856

GO:0050673

GO:0050678

GO:0050679

GO:0060045

GO:0060379

GO:0060412

GO:0060486

GO:0060716

GO:0060844

GO:0061344

GO:0061629

GO:0072089

GO:0072554

GO:0090263

GO:0097101

GO:0098542

GO:0120163

GO:0140110

GO:0140297

GO:1901186

GO:1901189

GO:2000138

GO:2000241

GO:2000647

HMNXSV003036990

Hs.278573.0.S1_3p_a_at

Hs.278573.0.S1_3p_s_at

Hs.278573.0.S1_3p_x_at

Hs.278573.1.S1_3p_a_at

ILMN_1708537

ILMN_1726913

ILMN_2316844

PH_hs_0029801

PH_hs_0032754

TC04001945.hg

TC04001946.hg

g7706215_3p_s_at

Participates

as a component of

as an input of

Inferred To

RBPJ [nucleoplasm] (Bos taurus)

RBPJ [nucleoplasm] (Canis familiaris)

RBPJ [nucleoplasm] (Gallus gallus)

RBPJ [nucleoplasm] (Sus scrofa)

lag-1 [nucleoplasm] (Caenorhabditis elegans)

cbf11 [nucleoplasm] (Schizosaccharomyces pombe)

rbpj [nucleoplasm] (Xenopus tropicalis)

rbpjb [nucleoplasm] (Danio rerio)

Su(H) [nucleoplasm] (Drosophila melanogaster)

Rbpj [nucleoplasm] (Mus musculus)

Rbpj [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005248218.1, NP_056958.3, XP_016863662.1, NP_976028.1, NP_976029.1, XP_011512142.1, XP_016863664.1, XP_016863661.1, XP_016863663.1, NP_005340.2

OpenTargets

ENSG00000168214

GeneCards

Q06330

HPA

ENSG00000168214-RBPJ

Ensembl

ENST00000507561, ENSG00000168214, ENST00000680928, ENST00000342295, ENST00000512671, ENSP00000347659, ENST00000681484, ENSP00000426872, ENSP00000305815, ENST00000355476, ENSP00000354528, ENST00000681093, ENSP00000345206, ENST00000342320, ENSP00000340124, ENST00000504423, ENST00000505958, ENSP00000505255, ENST00000348160, ENSP00000423644, ENST00000681264, ENSP00000504964, ENST00000361572, ENSP00000339699, ENSP00000505636, ENSP00000421804, ENSP00000505493, ENST00000345843, ENSP00000423907

PRO

Q06330

Pharos - Targets

Q06330

Orphanet

21412

PDB

2F8X, 3V79, 6PY8, 3NBN

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.913	13
UniProt:Q92585 MAML1	1	MAML1 [nucleoplasm] (R-HSA-212416)	0.892	8
UniProt:Q96K30 RITA1			0.729	10
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.688	3
UniProt:P12977 EBNA3			0.646	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.645	5
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676)	0.643	3
UniProt:P0C7T5 ATX1L			0.641	7
UniProt:P54253 ATX1			0.641	7
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.641	4
UniProt:Q6P3S6 FBX42			0.623	5
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.621	3
UniProt:Q01705 Notch1	20	Notch1 [endosome membrane] (R-MMU-9793910) p-NICD1 [nucleoplasm] (R-MMU-2064842) NICD1 [cytosol] (R-MMU-205738) N1' [plasma membrane] (R-MMU-206107) NTM' [extracellular region] (R-MMU-206219) NEXT1 [plasma membrane] (R-MMU-205889) NdeltaE [plasma membrane] (R-MMU-2063913) Fringe-modified NECD1 [plasma membrane] (R-MMU-2053928) Glc,GlcNAc-Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023154) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-MMU-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-MMU-1911511) NTM [plasma membrane] (R-MMU-206117) Notch1 Extracellular Domain (NECD1) [extracellular region] (R-MMU-2032285) Glc,Fuc-Pre-Notch1 [Golgi membrane] (R-MMU-2023160) Glc,Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-2023167) Fuc-Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-1985704) Pre-Notch1 [endoplasmic reticulum membrane] (R-MMU-1984030) nicd1 [nucleoplasm] (R-MMU-189582) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-MMU-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-MMU-157092)	0.611	3
UniProt:P0CJ62 RITA1			0.544	2
UniProt:Q9NW82 WDR70	1	WDR70 [nucleoplasm] (R-HSA-9770425)	0.527	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911504) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NEXT3 [plasma membrane] (R-HSA-157203) NICD3 [cytosol] (R-HSA-157647) NICD3 [nucleoplasm] (R-HSA-157928) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672)	0.527	2
UniProt:P12978 EBNA2			0.524	2
UniProt:P03204 EBNA6			0.524	3
UniProt:P03203 EBNA4			0.524	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.508	2
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.499	2
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.499	2

Cite Us!