Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RAPGEF4 [plasma membrane]
Stable Identifier
R-HSA-3008666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Rap guanine nucleotide exchange factor 4, RPGF4_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Rap1 signalling (Homo sapiens)
Activation of EPACs by cAMP (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
Rap1 cAMP-GEFs:cAMP [cytosol] (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
RAP1A exchanges GDP for GTP (Homo sapiens)
RAPGEF4:cAMP Complex [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
cAMP activates EPAC2 (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
RAPGEF4:cAMP Complex [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel (Homo sapiens)
RAPGEF4:cAMP Complex [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by membrane-associated GEFs (Homo sapiens)
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
RAPGEF4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WZA2 RAPGEF4
Gene Names
RAPGEF4, CGEF2, EPAC2
Chain
chain:1-1011
Reference Genes
BioGPS Gene:11069 RAPGEF4
COSMIC (genes):RAPGEF4 RAPGEF4
CTD Gene:11069 RAPGEF4
dbSNP Gene:11069 RAPGEF4
ENSEMBL:ENSG00000091428 RAPGEF4
HGNC:16626 RAPGEF4
Monarch:11069 RAPGEF4
NCBI Gene:11069 RAPGEF4
OMIM:606058 RAPGEF4
UCSC:Q8WZA2 RAPGEF4
Reference Transcript
RefSeq:NM_001282901.1 RAPGEF4
RefSeq:NM_001100397.1 RAPGEF4
RefSeq:NM_007023.3 RAPGEF4
RefSeq:XM_006712205.3 RAPGEF4
RefSeq:NM_001282900.1 RAPGEF4
RefSeq:NM_001282899.1 RAPGEF4
Other Identifiers
11069
11736717_a_at
11752396_a_at
11756731_a_at
16887763
205651_PM_x_at
205651_x_at
2515781
2515784
2515785
2515786
2515794
2515795
2515805
2515806
2515809
2515810
2515811
2515812
2515813
2515814
2515815
2515839
2515855
2515856
2515857
2515858
2515859
2515860
2515861
2515862
2515869
2515871
2515872
2515873
2515874
2515875
2515876
2515877
2515879
2515880
2515887
2515889
2515890
2515892
2515893
2515897
2515900
2515901
2515902
2515903
2515906
2515907
2515908
2515909
2515910
2515911
2515915
2515916
2515917
41011_i_at
41012_r_at
8046428
A_14_P131486
A_14_P133761
A_23_P17192
A_23_P17197
GE59426
GO:0002250
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006887
GO:0007186
GO:0007188
GO:0007189
GO:0007264
GO:0007265
GO:0016020
GO:0016192
GO:0017156
GO:0017157
GO:0030073
GO:0030552
GO:0030674
GO:0031267
GO:0032024
GO:0035556
GO:0046879
GO:0050796
GO:0060090
GO:0098686
GO:0098693
GO:0098772
HMNXSV003007525
ILMN_1661802
PH_hs_0005106
TC02001033.hg
g5901913_3p_at
Participates
as a member of
Rap1 cAMP-GEFs [plasma membrane] (Homo sapiens)
as an input of
cAMP activates EPAC2 (Homo sapiens)
as a component of
RAPGEF4:cAMP Complex [plasma membrane] (Homo sapiens)
Inferred To
gefP [plasma membrane]
(Dictyostelium discoideum)
ste6 [plasma membrane]
(Schizosaccharomyces pombe)
Rapgef4 [plasma membrane]
(Rattus norvegicus)
LTE1 [plasma membrane]
(Saccharomyces cerevisiae)
CDC25 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RAPGEF4 [plasma membrane]
(Dictyostelium discoideum)
Homologues of RAPGEF4 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of RAPGEF4 [plasma membrane]
(Schizosaccharomyces pombe)
efc25 [plasma membrane]
(Schizosaccharomyces pombe)
rapgef4 [plasma membrane]
(Xenopus tropicalis)
BUD5 [plasma membrane]
(Saccharomyces cerevisiae)
RAPGEF4 [plasma membrane]
(Bos taurus)
RAPGEF4 [plasma membrane]
(Caenorhabditis elegans)
RAPGEF4 [plasma membrane]
(Canis familiaris)
RAPGEF4 [plasma membrane]
(Gallus gallus)
RAPGEF4 [plasma membrane]
(Mus musculus)
RAPGEF4 [plasma membrane]
(Sus scrofa)
gefW [plasma membrane]
(Dictyostelium discoideum)
Epac [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
1293
ENSEMBL
ENSP00000440250
,
ENST00000538974
,
ENST00000397081
,
ENSP00000380271
,
ENSP00000380276
,
ENSP00000440135
,
ENST00000397087
,
ENST00000540783
OpenTargets
ENSG00000091428
HPA
ENSG00000091428-RAPGEF4
ZINC - Substances
RPGF4_HUMAN
ZINC target
Q8WZA2
PRO
Q8WZA2
Pharos - Targets
Q8WZA2
ZINC - Predictions - Purchasable
RPGF4_HUMAN
HMDB Protein
HMDBP02943
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UH65 SWAP70
1
SWAP70 [cytosol]
(R-HSA-9690929)
0.666
4
UniProt:Q96MC5 MERB1
0.666
4
UniProt:P49459 UBE2A
3
UBE2A [nucleoplasm]
(R-HSA-8852048)
Ub-C88-UBE2A [nucleoplasm]
(R-HSA-8864186)
UBE2A [cytosol]
(R-HSA-947617)
0.556
3
UniProt:Q9H4E7 DEF6
1
DEF6 [cytosol]
(R-HSA-9691487)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P05455 SSB
1
SSB [nucleoplasm]
(R-HSA-58418)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text