Reactome | NR1H3-1 [nucleoplasm]

NR1H3-1 [nucleoplasm]

Stable Identifier

R-HSA-3008623

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Oxysterols receptor LXR-alpha isoform 1

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
        
        NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)
        
        NR1H3-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13133-1 NR1H3

Gene Names

NR1H3, LXRA

Participates

as a component of

NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-NR1H3 [nucleoplasm]

Inferred To

NR1H3 [nucleoplasm] (Bos taurus)

NR1H3 [nucleoplasm] (Canis familiaris)

NR1H3 [nucleoplasm] (Gallus gallus)

NR1H3 [nucleoplasm] (Sus scrofa)

EcR [nucleoplasm] (Drosophila melanogaster)

Nr1h3 [nucleoplasm] (Mus musculus)

Nr1h3 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

602

OpenTargets

ENSG00000025434

ENSEMBL

ENST00000467728, ENSP00000384745, ENSP00000378793, ENST00000395397, ENST00000441012, ENST00000407404, ENSP00000387946, ENSP00000420656, ENSP00000385801, ENST00000405853, ENSG00000025434

ZINC - Substances

NR1H3_HUMAN

ZINC - Biogenic

NR1H3_HUMAN

ZINC target

Q13133

PRO

Q13133

GlyGen

Q13133

PDB

3IPS, 5AVI, 3IPQ, 1UHL, 5AVL, 3IPU, 5HJS

ZINC - Metabolites

NR1H3_HUMAN

HPA

ENSG00000025434-NR1H3

GeneCards

NR1H3

Pharos - Targets

Q13133

ZINC - Predictions - Purchasable

NR1H3_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.742	7
UniProt:Q15788 NCOA1	3	NCOA1 [nucleoplasm] (R-HSA-442496) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291)	0.691	15
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.666	4
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.642	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.611	5
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.609	8
UniProt:O60869 EDF1			0.581	4
UniProt:Q99750 MDFI			0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

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