Reactome | NR1H3-1 [nucleoplasm]

NR1H3-1 [nucleoplasm]

Stable Identifier

R-HSA-3008623

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Oxysterols receptor LXR-alpha isoform 1

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
        
        NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)
        
        NR1H3-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13133-1 NR1H3

Gene Names

NR1H3, LXRA

Other Identifiers

10062

11719393_a_at

16724485

1UHL

203920_at

33106_at

3329686

3329689

3329690

3329691

3329692

3329693

3329694

3329695

3329696

3329697

3329699

3329700

3329701

3329702

3329703

3329705

3329707

3329708

3329711

3329713

3329714

3329715

3329716

3329717

3329718

3329725

36443

37109

3IPQ

3IPS

3IPU

512_at

5AVI

5AVL

5HJS

7939751

A_14_P122332

A_23_P47135

A_33_P3237775

AAA85856

AAH08819

AAH41172

AC018410

ADZ17330

AK290614

B4DXU5

B5MBY7

BAF83303

BC008819

BC041172

C9J2C8

C9J4R0

C9JBS2

C9JCS0

C9JEC2

C9JJ16

C9JTS4

CAB037109

CCDS44584

CCDS44585

CCDS7929

CH471064

E9PID2

E9PLL4

E9PPA1

EAW67942

EAW67943

EAW67944

EAW67947

EAW67948

EAW67949

ENSG00000025434

ENSP00000378793

ENSP00000384745

ENSP00000385801

ENSP00000387946

ENSP00000420656

ENST00000395397

ENST00000395397.7

ENST00000405853

ENST00000405853.7

ENST00000407404

ENST00000407404.5

ENST00000441012

ENST00000441012.6

ENST00000467728

ENST00000467728.5

EntrezGene:10062

EntrezGene:NR1H3

F1D8N1

F8WC63

F8WEY6

g5031892_3p_at

GE81543

GO:0000122

GO:0000228

GO:0000790

GO:0000976

GO:0000977

GO:0000981

GO:0002376

GO:0003674

GO:0003677

GO:0003700

GO:0003707

GO:0003713

GO:0004879

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006355

GO:0006367

GO:0006629

GO:0006810

GO:0006950

GO:0007165

GO:0007275

GO:0008134

GO:0008150

GO:0008270

GO:0008289

GO:0009058

GO:0010745

GO:0010867

GO:0010870

GO:0010875

GO:0010887

GO:0015031

GO:0015485

GO:0016192

GO:0030154

GO:0030374

GO:0030522

GO:0032270

GO:0032369

GO:0032376

GO:0032570

GO:0032810

GO:0032991

GO:0034145

GO:0034641

GO:0038023

GO:0042592

GO:0042632

GO:0042752

GO:0043031

GO:0043167

GO:0043226

GO:0043235

GO:0043277

GO:0043401

GO:0043565

GO:0044212

GO:0044281

GO:0045723

GO:0045893

GO:0045944

GO:0046872

GO:0048550

GO:0048856

GO:0050728

GO:0051006

GO:0055088

GO:0055092

GO:0060336

GO:0070328

GO:0071222

GO:0090188

GO:0090341

GO:0090575

GO:0120163

GO:2000325

HGNC:7966

HPA036443

HQ692819

ILMN_1814022

IPR000536

IPR001628

IPR001723

IPR013088

IPR023257

IPR035500

MIM:602423

NM_001130101

NM_001130102

NM_005693

NP_001123573

NP_001123574

NP_005684

NR1H3

NR1H3-201

NR1H3-203

NR1H3-204

NR1H3-211

NR1H3-217

PF00104

PF00105

PH_hs_0033433

PR00047

PR00398

PR02034

SM00399

SM00430

TC11000405.hg

U22662

U22662_at

UPI000002AFBC

UPI000007457E

UPI000013050C

XM_005252706

XM_005252713

XM_011519805

XM_011519807

XM_011519808

XM_017017056

XM_017017057

XM_024448284

XM_024448285

XM_024448286

XM_024448287

XM_024448288

XM_024448289

XM_024448297

XM_024448298

XP_005252763

XP_005252770

XP_011518107

XP_011518109

XP_011518110

XP_016872545

XP_016872546

XP_024304052

XP_024304053

XP_024304054

XP_024304055

XP_024304056

XP_024304057

XP_024304065

XP_024304066

Participant Of

hasComponent

NR1H3:hydroxycholesterol [nucleoplasm]

hasMember

NR [nucleoplasm]

Other forms of this molecule

SUMO2,3-NR1H3 [nucleoplasm]

Inferred To

NR1H3-1 [nucleoplasm] (Bos taurus)

NR1H3-1 [nucleoplasm] (Caenorhabditis elegans)

NR1H3-1 [nucleoplasm] (Canis familiaris)

NR1H3-1 [nucleoplasm] (Danio rerio)

NR1H3-1 [nucleoplasm] (Drosophila melanogaster)

NR1H3-1 [nucleoplasm] (Gallus gallus)

NR1H3-1 [nucleoplasm] (Mus musculus)

NR1H3-1 [nucleoplasm] (Rattus norvegicus)

NR1H3-1 [nucleoplasm] (Sus scrofa)

Homologues of NR1H3-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006718176.1, XP_005252762.1, XP_005252766.1, NP_001123574.1, XP_005252764.1, NP_005684.2, XP_005252767.1, XP_016872547.1, XP_005252770.1, XP_006718179.1, XP_006718178.1, XP_005252763.1, XP_011518107.1, XP_006718175.1, NP_001123573.1

ZINC - Metabolites

NR1H3_HUMAN

OpenTargets

ENSG00000025434

GeneCards

Q13133

ZINC - Substances

NR1H3_HUMAN

ZINC target

Q13133

ZINC - Biogenic

NR1H3_HUMAN

PRO

Q13133

ZINC - Predictions - Purchasable

NR1H3_HUMAN

PDB

5AVI, 3IPQ, 3IPU, 1UHL, 5AVL, 3IPS, 5HJS

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.742	7
UniProt:Q15788 NCOA1	3	NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) SUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 [nucleoplasm] (R-HSA-442496)	0.691	15
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) SUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.611	5
UniProt:P19793 RXRA	4	p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757) SUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.609	8
UniProt:O60869 EDF1			0.581	4
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [nucleoplasm] (R-HSA-442501) NCOR1 [cytosol] (R-HSA-1253310)	0.525	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2