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NR1H3-1 [nucleoplasm]
Stable Identifier
R-HSA-3008623
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Oxysterols receptor LXR-alpha isoform 1
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR1H3-1 [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR1H3-1 [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR1H3-1 [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
NR1H3-1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)
NR1H3-1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13133-1 NR1H3
Gene Names
NR1H3, LXRA
Other Identifiers
10062
11719393_a_at
16724485
203920_at
33106_at
3329686
3329689
3329690
3329691
3329692
3329693
3329694
3329695
3329696
3329697
3329699
3329700
3329701
3329702
3329703
3329705
3329707
3329708
3329711
3329713
3329714
3329715
3329716
3329717
3329718
3329725
512_at
7939751
A_14_P122332
A_23_P47135
A_33_P3237775
GE81543
GO:0000122
GO:0000228
GO:0000790
GO:0000976
GO:0000977
GO:0000981
GO:0002376
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006355
GO:0006367
GO:0006629
GO:0006810
GO:0006950
GO:0007165
GO:0008134
GO:0008150
GO:0008270
GO:0008289
GO:0009058
GO:0010745
GO:0010867
GO:0010870
GO:0010875
GO:0010887
GO:0015031
GO:0015485
GO:0016192
GO:0030154
GO:0030522
GO:0032270
GO:0032369
GO:0032376
GO:0032570
GO:0032810
GO:0032991
GO:0034145
GO:0034641
GO:0036151
GO:0038023
GO:0042025
GO:0042592
GO:0042632
GO:0042752
GO:0043031
GO:0043167
GO:0043226
GO:0043235
GO:0043277
GO:0043565
GO:0044281
GO:0045723
GO:0045893
GO:0045944
GO:0046872
GO:0048550
GO:0050728
GO:0051006
GO:0055088
GO:0055092
GO:0060336
GO:0070328
GO:0071222
GO:0090188
GO:0090341
GO:0090575
GO:0120163
GO:1903573
GO:2000325
ILMN_1814022
PH_hs_0033433
TC11000405.hg
U22662_at
g5031892_3p_at
Participant Of
hasComponent
NR1H3:hydroxycholesterol [nucleoplasm]
hasMember
NR [nucleoplasm]
Other forms of this molecule
SUMO2,3-NR1H3 [nucleoplasm]
Inferred To
NR1H3 [nucleoplasm] (Bos taurus)
NR1H3 [nucleoplasm] (Canis familiaris)
NR1H3 [nucleoplasm] (Gallus gallus)
nhr-8 [nucleoplasm] (Caenorhabditis elegans)
nr1h3 [nucleoplasm] (Danio rerio)
LXRA [nucleoplasm] (Sus scrofa)
daf-12 [nucleoplasm] (Caenorhabditis elegans)
nhr-48 [nucleoplasm] (Caenorhabditis elegans)
EcR [nucleoplasm] (Drosophila melanogaster)
Nr1h3 [nucleoplasm] (Mus musculus)
Nr1h3 [nucleoplasm] (Rattus norvegicus)
Homologues of NR1H3-1 [nucleoplasm] (Caenorhabditis elegans)
Homologues of NR1H3-1 [nucleoplasm] (Drosophila melanogaster)
Hr96 [nucleoplasm] (Drosophila melanogaster)
unc-55 [nucleoplasm] (Caenorhabditis elegans)
Cross References
RefSeq
XP_005252764.1
,
XP_006718176.1
,
XP_005252770.1
,
XP_016872547.1
,
XP_006718178.1
,
XP_005252762.1
,
XP_011518107.1
,
NP_001123573.1
,
NP_005684.2
,
XP_005252766.1
,
XP_005252763.1
,
XP_006718179.1
,
NP_001123574.1
,
XP_005252767.1
,
XP_006718175.1
ZINC - Metabolites
NR1H3_HUMAN
OpenTargets
ENSG00000025434
ZINC - Substances
NR1H3_HUMAN
HPA
ENSG00000025434-NR1H3
GeneCards
Q13133
ZINC - Biogenic
NR1H3_HUMAN
Ensembl
ENSP00000420656
,
ENST00000441012
,
ENSG00000025434
,
ENST00000407404
,
ENST00000395397
,
ENST00000467728
,
ENSP00000378793
,
ENSP00000385801
,
ENST00000405853
,
ENSP00000384745
,
ENSP00000387946
ZINC target
Q13133
PRO
Q13133
ZINC - Predictions - Purchasable
NR1H3_HUMAN
PDB
5HJS
,
5AVI
,
3IPQ
,
3IPU
,
5AVL
,
1UHL
,
3IPS
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48443 RXRG
1
RXRG [nucleoplasm]
(R-HSA-446170)
0.742
7
UniProt:Q15788 NCOA1
3
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
SUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.691
15
UniProt:Q07869 PPARA
2
PPARA [nucleoplasm]
(R-HSA-400186)
SUMO1-K185-PPARA [nucleoplasm]
(R-HSA-4341099)
0.611
5
UniProt:P19793 RXRA
4
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
SUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.609
8
UniProt:O60869 EDF1
0.581
4
UniProt:P28702 RXRB
1
RXRB [nucleoplasm]
(R-HSA-446163)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.525
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
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