Reactome | NR1H3-1 [nucleoplasm]

NR1H3-1 [nucleoplasm]

Stable Identifier

R-HSA-3008623

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Oxysterols receptor LXR-alpha isoform 1

Icon

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of intracellular receptors (Homo sapiens)
        
        HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
        
        NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)
        
        NR1H3-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13133-1 NR1H3

Gene Names

NR1H3, LXRA

Other Identifiers

10062

11719393_a_at

16724485

203920_PM_at

203920_at

33106_at

3329686

3329689

3329690

3329691

3329692

3329693

3329694

3329695

3329696

3329697

3329699

3329700

3329701

3329702

3329703

3329705

3329707

3329708

3329711

3329713

3329714

3329715

3329716

3329717

3329718

3329725

512_at

7939751

A_14_P122332

A_23_P47135

A_33_P3237775

GE81543

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001228

GO:0002376

GO:0003677

GO:0003700

GO:0004879

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006629

GO:0006954

GO:0008270

GO:0008289

GO:0009755

GO:0010745

GO:0010867

GO:0010875

GO:0010887

GO:0015485

GO:0016071

GO:0016192

GO:0022600

GO:0023052

GO:0030154

GO:0030522

GO:0031490

GO:0032369

GO:0032376

GO:0032411

GO:0032570

GO:0032810

GO:0032991

GO:0034145

GO:0036151

GO:0042632

GO:0042752

GO:0042789

GO:0043031

GO:0043226

GO:0043235

GO:0043277

GO:0043565

GO:0044255

GO:0045723

GO:0045861

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048550

GO:0050728

GO:0051006

GO:0051247

GO:0055088

GO:0055092

GO:0060089

GO:0060336

GO:0070328

GO:0071222

GO:0090188

GO:0090341

GO:0090575

GO:0098542

GO:0120163

GO:1903573

HMNXSV003022469

ILMN_1814022

PH_hs_0033433

TC11000405.hg

U22662_at

g5031892_3p_at

Participates

as a component of

NR1H3:hydroxycholesterol [nucleoplasm] (Homo sapiens)

as a member of

NR [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2,3-NR1H3 [nucleoplasm]

Inferred To

NR1H3 [nucleoplasm] (Bos taurus)

NR1H3 [nucleoplasm] (Gallus gallus)

NR1H3 [nucleoplasm] (Sus scrofa)

EcR [nucleoplasm] (Drosophila melanogaster)

NR1H3-1 [nucleoplasm] (Canis familiaris)

NR1H3-1 [nucleoplasm] (Danio rerio)

Nr1h3 [nucleoplasm] (Mus musculus)

Nr1h3 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_005252762.1, NP_005684.2, XP_005252767.1, XP_006718176.1, XP_006718175.1, XP_005252766.1, XP_016872547.1, NP_001123574.1, XP_005252763.1, XP_005252770.1, XP_006718179.1, NP_001123573.1, XP_011518107.1, XP_005252764.1, XP_006718178.1

Guide to Pharmacology - Targets

602

OpenTargets

ENSG00000025434

ZINC - Substances

NR1H3_HUMAN

ZINC target

Q13133

ZINC - Biogenic

NR1H3_HUMAN

PRO

Q13133

PDB

5AVL, 1UHL, 5HJS, 3IPQ, 3IPU, 5AVI, 3IPS

ZINC - Metabolites

NR1H3_HUMAN

GeneCards

Q13133

HPA

ENSG00000025434-NR1H3

Ensembl

ENSG00000025434, ENST00000441012, ENSP00000420656, ENSP00000378793, ENST00000405853, ENST00000467728, ENST00000395397, ENST00000407404, ENSP00000385801, ENSP00000387946, ENSP00000384745

Pharos - Targets

Q13133

ZINC - Predictions - Purchasable

NR1H3_HUMAN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.742	7
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.691	15
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.611	5
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.609	8
UniProt:O60869 EDF1			0.581	4
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.525	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2