Reactome | MYO6 [cytosol]

MYO6 [cytosol]

Stable Identifier

R-HSA-3006692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Unconventional myosin-VI, MYO6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P98082 DAB2

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
      - Trafficking of AMPA receptors (Homo sapiens)
        
        Trafficking of GluR1-containing AMPA receptors (Homo sapiens)
        
        MYO6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UM54 MYO6

Gene Names

MYO6, KIAA0389

Chain

chain:1-1294

Reference Genes

BioGPS Gene:4646 MYO6

COSMIC (genes):MYO6 MYO6

CTD Gene:4646 MYO6

dbSNP Gene:4646 MYO6

ENSEMBL:ENSG00000196586 MYO6

ENSEMBL_homo_sapiens_GENE:ENSG00000196586.17 MYO6

HGNC:7605 MYO6

KEGG Gene (Homo sapiens):4646 MYO6

Monarch:4646 MYO6

NCBI Gene:4646 MYO6

OMIM:600970 MYO6

UCSC:Q9UM54 MYO6

Reference Transcript

Other Identifiers

11715908_at

11715909_s_at

11715910_a_at

11715911_at

11746483_a_at

17010461

203215_PM_s_at

203215_s_at

203216_PM_s_at

203216_s_at

210480_PM_s_at

210480_s_at

2914071

2914082

2914083

2914084

2914087

2914089

2914090

2914092

2914093

2914095

2914096

2914097

2914098

2914100

2914101

2914102

2914103

2914104

2914106

2914107

2914109

2914111

2914113

2914114

2914115

2914117

2914118

2914120

2914121

2914122

2914129

2914132

2914138

2914140

2914142

2914145

2914146

2914147

2914148

2914149

2914151

2914152

2914153

2914155

33375_at

4646

75828_r_at

8120783

A_14_P136401

A_14_P137475

A_23_P255952

A_24_P283225

A_33_P3539345

GE53099

GO:0000146

GO:0000166

GO:0001726

GO:0003774

GO:0003779

GO:0005515

GO:0005516

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005776

GO:0005794

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005902

GO:0005905

GO:0005938

GO:0006886

GO:0006897

GO:0007010

GO:0007015

GO:0007605

GO:0008092

GO:0009410

GO:0015031

GO:0015629

GO:0016020

GO:0016192

GO:0016459

GO:0016461

GO:0023052

GO:0030048

GO:0030050

GO:0030136

GO:0030139

GO:0030154

GO:0030175

GO:0030330

GO:0030665

GO:0031410

GO:0031941

GO:0031965

GO:0032587

GO:0032991

GO:0042472

GO:0042491

GO:0042802

GO:0042995

GO:0043226

GO:0043531

GO:0045177

GO:0045334

GO:0048471

GO:0048856

GO:0050877

GO:0051015

GO:0051046

GO:0060001

GO:0070062

GO:0071944

GO:0140657

HMNXSV003035387

HMNXSV003040723

Hs.22564.0.S1_3p_a_at

ILMN_1727080

PH_hs_0035540

TC06000747.hg

TC06002880.hg

g4826845_3p_a_at

g9280815_3p_a_at

Participates

as a candidate of

as an input of

Trafficking of GluR1-containing AMPA receptors (Homo sapiens)

Other forms of this molecule

MYO6 [plasma membrane]

MYO6 [lysosomal membrane]

Inferred To

MYO6 [cytosol] (Bos taurus)

MYO6 [cytosol] (Caenorhabditis elegans)

MYO6 [cytosol] (Canis familiaris)

MYO6 [cytosol] (Dictyostelium discoideum)

MYO6 [cytosol] (Drosophila melanogaster)

MYO6 [cytosol] (Gallus gallus)

MYO6 [cytosol] (Mus musculus)

MYO6 [cytosol] (Rattus norvegicus)

MYO6 [cytosol] (Saccharomyces cerevisiae)

MYO6 [cytosol] (Schizosaccharomyces pombe)

MYO6 [cytosol] (Sus scrofa)

Homologues of MYO6 [cytosol] (Dictyostelium discoideum)

Homologues of MYO6 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYO6 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001287828.1, NP_004990.3

OpenTargets

ENSG00000196586

GeneCards

Q9UM54

HPA

ENSG00000196586-MYO6

Ensembl

ENST00000369985, ENST00000369977, ENSP00000478013, ENSP00000359002, ENSG00000196586, ENSP00000358994, ENST00000615563

PRO

Q9UM54

Pharos - Targets

Q9UM54

Orphanet

16509

HMDB Protein

HMDBP07828

PDB

2N12, 2N0Z, 2N11, 2N13, 6E5N, 2N10, 8W41, 6J56

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.7	6
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.688	3
UniProt:Q96II8 LRCH3			0.649	4
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.632	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	22
UniProt:Q6ZVM7 TM1L2			0.613	3
UniProt:Q96N67 DOCK7	1	DOCK7 [cytosol] (R-HSA-1012970)	0.569	3
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.564	2
UniProt:P98082 DAB2	3	DAB2 [cytosol] (R-HSA-8862456) DAB2 [lysosomal membrane] (R-HSA-2980807) DAB2 [plasma membrane] (R-HSA-2980808)	0.543	3
UniProt:Q9NWN3 FBX34			0.527	2
UniProt:Q9NWM3 CUED1			0.527	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	2
UniProt:Q9ULJ8 NEB1			0.527	2
UniProt:Q9NZR1 TMOD2	1	TMOD2 [cytosol] (R-HSA-5694032)	0.527	2
UniProt:P0CG38 POTEI			0.527	2
UniProt:Q562R1 ACTBL			0.527	2
UniProt:O60784 TOM1	3	TOM1 [azurophil granule membrane] (R-HSA-6799348) TOM1 [plasma membrane] (R-HSA-6806274) TOM1 [specific granule membrane] (R-HSA-6800923)	0.527	2
UniProt:Q9Z0G0	1	Gipc1 [cytoplasm] (R-MMU-9839329)	0.524	4

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