Reactome | ITSN1 [cytosol]

ITSN1 [cytosol]

Stable Identifier

R-HSA-3006481

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Intersectin-1, ITSN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P42566 EPS15

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        EPHB binds ITSN1 (Homo sapiens)
        
        ITSN1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15811 ITSN1

Gene Names

ITSN1, ITSN, SH3D1A

Chain

chain:1-1721

Reference Genes

BioGPS Gene:6453 ITSN1

COSMIC (genes):ITSN1 ITSN1

CTD Gene:6453 ITSN1

dbSNP Gene:6453 ITSN1

ENSEMBL:ENSG00000205726 ITSN1

ENSEMBL_homo_sapiens_GENE:ENSG00000205726.15 ITSN1

HGNC:6183 ITSN1

KEGG Gene (Homo sapiens):6453 ITSN1

Monarch:6453 ITSN1

NCBI Gene:6453 ITSN1

OMIM:602442 ITSN1

UCSC:Q15811 ITSN1

Reference Transcript

Other Identifiers

11722550_a_at

11722551_s_at

11722552_x_at

11736139_at

11736140_a_at

11736141_a_at

11745505_x_at

11746778_a_at

11750609_a_at

11759181_at

11760588_at

1557279_PM_at

1557279_at

1557280_PM_s_at

1557280_s_at

16922327

207322_PM_at

207322_at

209297_PM_at

209297_at

209298_PM_s_at

209298_s_at

230042_PM_at

230042_at

2848453

2848455

2848457

2848460

35776_PM_at

35776_at

3918780

3918790

3918791

3918792

3918793

3918796

3918805

3918806

3918807

3918810

3918811

3918813

3918814

3918815

3918817

3918818

3918820

3918821

3918823

3918824

3918826

3918827

3918829

3918831

3918834

3918836

3918843

3918845

3918846

3918853

3918855

3918861

3918865

3918866

3918867

3918868

3918869

3918870

3918871

3918881

3918884

3918890

3918896

3918898

3918903

3918904

3918905

3918906

3918907

3918908

3918909

3918910

3918911

3918912

3918913

3918914

3918915

3918916

3918917

3918918

3918919

3918920

3918921

3918937

3918939

3918941

488_at

4898019C_3p_x_at

55412_at

6453

8068305

A_14_P104004

A_14_P116756

A_23_P252962

A_23_P91504

A_24_P111061

A_24_P918500

A_33_P3250595

A_33_P3277728

GE54587

GE736570

GE79207

GE84040

GE88249

GO:0005085

GO:0005509

GO:0005515

GO:0005634

GO:0005635

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0005905

GO:0006887

GO:0006897

GO:0008104

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0023052

GO:0030027

GO:0031410

GO:0035556

GO:0042734

GO:0042995

GO:0043005

GO:0043226

GO:0045202

GO:0046872

GO:0051056

GO:0055037

GO:0060090

GO:0070064

GO:0097708

GO:0098772

GO:0150007

HMNXSV003025357

HMNXSV003039136

Hs.90221.0.A1_3p_at

Hs.90221.0.A1_3p_x_at

Hs2.407005.1.S1_3p_s_at

ILMN_1651848

ILMN_1672741

ILMN_1718769

ILMN_1861392

PH_hs_0005037

PH_hs_0035443

RNA95212|RNS_294_182

TC21000131.hg

TC21000681.hg

TC21000683.hg

TC21000684.hg

TC21000685.hg

g4504796_3p_at

g4808824_3p_s_at

p26168

p26785

Participates

as a member of

as a candidate of

CDC42 GEFs [cytosol] (Homo sapiens)

as an input of

EPHB binds ITSN1 (Homo sapiens)

as a component of

Inferred To

Homologues of ITSN1 [cytosol] (Canis familiaris)

Homologues of ITSN1 [cytosol] (Plasmodium falciparum)

Homologues of ITSN1 [cytosol] (Saccharomyces cerevisiae)

Homologues of ITSN1 [cytosol] (Schizosaccharomyces pombe)

ITSN1 [cytosol] (Bos taurus)

ITSN1 [cytosol] (Canis familiaris)

ITSN1 [cytosol] (Gallus gallus)

ITSN1 [cytosol] (Mus musculus)

ITSN1 [cytosol] (Plasmodium falciparum)

ITSN1 [cytosol] (Rattus norvegicus)

ITSN1 [cytosol] (Saccharomyces cerevisiae)

ITSN1 [cytosol] (Schizosaccharomyces pombe)

ITSN1 [cytosol] (Sus scrofa)

Dap160 [cytosol] (Drosophila melanogaster)

LOC119867035 [cytosol] (Canis familiaris)

itsn-1 [cytosol] (Caenorhabditis elegans)

pan1 [cytosol] (Schizosaccharomyces pombe)

ucp8 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of ITSN1 [cytosol] (Danio rerio)

IRS4 [cytosol] (Saccharomyces cerevisiae)

end3 [cytosol] (Schizosaccharomyces pombe)

eps15 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001317940.1, XP_016883922.1, XP_016883917.1, NP_001317938.1, NP_001001132.1, XP_016883929.1, XP_011527995.1, NP_001317939.1, XP_011527994.1, NP_003015.2, NP_001317941.1, XP_016883921.1

OpenTargets

ENSG00000205726

GeneCards

Q15811

HPA

ENSG00000205726-ITSN1

Ensembl

ENST00000399353, ENSP00000370719, ENSP00000382290, ENSP00000382275, ENSP00000382286, ENST00000399367, ENSP00000370691, ENST00000381291, ENST00000399338, ENST00000399349, ENSP00000382301, ENST00000381318, ENST00000399352, ENSP00000382289, ENSG00000205726

PRO

Q15811

Pharos - Targets

Q15811

Orphanet

28565

PDB

6H5T, 6GBU, 2KHN, 5HZI, 2KGR, 3FIA, 3QBV, 5HZK, 1KI1, 5HZJ, 4IIM

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.764	5
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.738	5
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.729	12
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.722	8
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.713	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.704	5
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.623	3
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.573	2
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.564	3
UniProt:Q3UQN2	1	Fcho2 [cytosol] (R-MMU-8862260)	0.557	3
UniProt:Q9NRI5 DISC1			0.553	4
UniProt:P61968 LMO4			0.553	3
UniProt:Q12840 KIF5A	1	KIF5A [cytosol] (R-HSA-983190)	0.553	2
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.553	2
UniProt:P60953-1 CDC42			0.544	2
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.527	3
UniProt:P60880 SNAP25	7	SNAP25(1-197) [plasma membrane] (R-HSA-3004546) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [plasma membrane] (R-HSA-2029017)	0.502	2

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