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SMAD6 [cytosol]
Stable Identifier
R-HSA-3006350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mothers against decapentaplegic homolog 6, SMAD6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43541 SMAD6
Gene Names
SMAD6, MADH6
Chain
chain:1-496
Reference Genes
BioGPS Gene:4091 SMAD6
COSMIC (genes):SMAD6 SMAD6
CTD Gene:4091 SMAD6
dbSNP Gene:4091 SMAD6
ENSEMBL:ENSG00000137834 SMAD6
ENSEMBL:ENSG00000137834.15 SMAD6
HGNC:6772 SMAD6
KEGG Gene (Homo sapiens):4091 SMAD6
Monarch:4091 SMAD6
NCBI Gene:4091 SMAD6
OMIM:602931 SMAD6
UCSC:O43541 SMAD6
Reference Transcript
RefSeq:XM_011521561.2 SMAD6
RefSeq:NM_005585.4 SMAD6
Other Identifiers
11730337_at
11730338_a_at
11730339_a_at
16802232
1955_s_at
207069_PM_s_at
207069_s_at
209886_PM_s_at
209886_s_at
3598773
3598774
3598775
3598776
3598777
3598778
3598779
3598780
3598781
3598782
3598783
3598784
3598785
3598795
3598798
3598800
3598818
3598819
4091
7984353
A_14_P113032
A_23_P65812
A_33_P3220470
GE54281
GO:0000785
GO:0000976
GO:0001657
GO:0002376
GO:0003148
GO:0003170
GO:0003180
GO:0003183
GO:0003184
GO:0003281
GO:0003677
GO:0003682
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005794
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006955
GO:0007155
GO:0007179
GO:0007352
GO:0008285
GO:0009653
GO:0010468
GO:0010991
GO:0012501
GO:0016604
GO:0023052
GO:0030154
GO:0030279
GO:0030509
GO:0030512
GO:0030514
GO:0031589
GO:0031625
GO:0032496
GO:0032991
GO:0034616
GO:0034713
GO:0035904
GO:0036211
GO:0042802
GO:0043066
GO:0043226
GO:0043627
GO:0045444
GO:0045668
GO:0046872
GO:0048856
GO:0060394
GO:0060395
GO:0060976
GO:0065003
GO:0070410
GO:0070411
GO:0070412
GO:0070698
GO:0071144
GO:0098772
GO:0140416
GO:1902895
HMNXSV003039151
Hs.153863.1.A1_3p_a_at
ILMN_1767068
ILMN_1910628
PH_hs_0009256
TC15000616.hg
TC15002247.hg
U59914_at
g5031898_3p_a_at
Participates
as a member of
I-SMAD [cytosol] (Homo sapiens)
as an output of
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
Inferred To
LOC564395 [cytosol]
(Danio rerio)
smad6 [cytosol]
(Xenopus tropicalis)
tag-68 [cytosol]
(Caenorhabditis elegans)
Homologues of SMAD6 [cytosol]
(Gallus gallus)
Smad6 [cytosol]
(Rattus norvegicus)
SMAD6 [cytosol]
(Bos taurus)
SMAD6 [cytosol]
(Canis familiaris)
SMAD6 [cytosol]
(Gallus gallus)
SMAD6 [cytosol]
(Mus musculus)
SMAD6 [cytosol]
(Sus scrofa)
Dad [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_011519863.1
,
NP_005576.3
OpenTargets
ENSG00000137834
GeneCards
O43541
HPA
ENSG00000137834-SMAD6
Ensembl
ENSG00000137834
,
ENSP00000452955
,
ENSP00000288840
,
ENST00000557916
,
ENST00000288840
PRO
O43541
Pharos - Targets
O43541
Orphanet
21410
HMDB Protein
HMDBP14504
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51817 PRKX
1
PRKX [nucleoplasm]
(R-HSA-3222308)
0.633
5
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
SMAD1 [cytosol]
(R-HSA-201468)
0.567
4
UniProt:O43541 SMAD6
1
SMAD6 [cytosol]
(R-HSA-3006350)
0.508
2
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