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SMURF1 [nucleoplasm]
Stable Identifier
R-HSA-3004548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q53GL0 PKHO1
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7 binds to SMURF1 (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCE7 SMURF1
Gene Names
SMURF1, KIAA1625
Chain
chain:1-757
Reference Genes
BioGPS Gene:57154 SMURF1
COSMIC (genes):SMURF1 SMURF1
CTD Gene:57154 SMURF1
dbSNP Gene:57154 SMURF1
ENSEMBL:ENSG00000198742 SMURF1
ENSEMBL_homo_sapiens_GENE:ENSG00000198742.10 SMURF1
HGNC:16807 SMURF1
KEGG Gene (Homo sapiens):57154 SMURF1
Monarch:57154 SMURF1
NCBI Gene:57154 SMURF1
OMIM:605568 SMURF1
UCSC:Q9HCE7 SMURF1
Reference Transcript
RefSeq:NM_181349.2 SMURF1
RefSeq:NM_001199847.1 SMURF1
RefSeq:NM_020429.2 SMURF1
Other Identifiers
11722957_a_at
11736974_a_at
17060186
212666_PM_at
212666_at
212668_PM_at
212668_at
215458_PM_s_at
215458_s_at
3063088
3063089
3063090
3063091
3063092
3063093
3063094
3063096
3063097
3063098
3063100
3063102
3063105
3063107
3063109
3063111
3063114
3063115
3063116
3063117
3063118
3063119
3063120
3063122
3063124
3063156
3063157
37504_at
57154
63399_at
8141241
A_23_P353316
A_23_P398254
GE56944
GO:0000209
GO:0003824
GO:0004842
GO:0005160
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006511
GO:0006611
GO:0006886
GO:0006913
GO:0006914
GO:0007398
GO:0008289
GO:0016020
GO:0016567
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0030424
GO:0030509
GO:0030512
GO:0030514
GO:0032801
GO:0032926
GO:0036211
GO:0043025
GO:0043161
GO:0043226
GO:0045773
GO:0048856
GO:0060071
GO:0061024
GO:0061630
GO:0061736
GO:0061753
GO:0070062
GO:0070411
GO:0070412
GO:0070697
GO:0071211
GO:0072659
GO:0140096
GO:1903861
GO:2000060
HMNXSV003028849
Hs.119120.0.S2_3p_at
Hs.119120.1.S1_3p_a_at
ILMN_1756615
ILMN_1779492
PH_hs_0040932
TC07001639.hg
Participates
as a member of
SMURF [nucleoplasm] (Homo sapiens)
as a component of
Smad7:SMURF1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
as an input of
Smad7 binds SMURF1 (Homo sapiens)
SMAD7 binds to SMURF1 (Homo sapiens)
Other forms of this molecule
SMURF1 [cytosol]
Inferred To
Smurf [nucleoplasm]
(Drosophila melanogaster)
smurf1 [nucleoplasm]
(Danio rerio)
SMURF1 [nucleoplasm]
(Bos taurus)
SMURF1 [nucleoplasm]
(Canis familiaris)
SMURF1 [nucleoplasm]
(Gallus gallus)
SMURF1 [nucleoplasm]
(Sus scrofa)
Smurf1 [nucleoplasm]
(Mus musculus)
Smurf1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_851994.1
,
NP_065162.1
,
NP_001186776.1
OpenTargets
ENSG00000198742
IntEnz
2.3.2.26
HPA
ENSG00000198742-SMURF1
GeneCards
Q9HCE7
Ensembl
ENST00000361368
,
ENST00000361125
,
ENSG00000198742
,
ENSP00000355326
,
ENSP00000354621
PRO
Q9HCE7
Pharos - Targets
Q9HCE7
PDB
2LB0
,
3PYC
,
2LAZ
,
2LB1
,
2LTX
HMDB Protein
HMDBP09298
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.645
6
UniProt:Q53GL0 PKHO1
0.623
2
UniProt:P61289 PSME3
2
PSME3 [cytosol]
(R-HSA-68816)
PSME3 [nucleoplasm]
(R-HSA-174310)
0.593
5
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.573
2
UniProt:Q9Y5W3 KLF2
0.508
2
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