Reactome | SMURF1 [nucleoplasm]

SMURF1 [nucleoplasm]

Stable Identifier

R-HSA-3004548

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        SMURFs ubiquitinate RUNX3 (Homo sapiens)
        
        SMURF [nucleoplasm] (Homo sapiens)
        
        SMURF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HCE7 SMURF1

Gene Names

SMURF1, KIAA1625

Chain

chain:1-757

Reference Genes

BioGPS Gene:57154 SMURF1

COSMIC (genes):SMURF1 SMURF1

CTD Gene:57154 SMURF1

dbSNP Gene:57154 SMURF1

ENSEMBL:ENSG00000198742 SMURF1

ENSEMBL:ENSG00000284126 SMURF1

HGNC:16807 SMURF1

KEGG Gene (Homo sapiens):57154 SMURF1

Monarch:57154 SMURF1

NCBI Gene:57154 SMURF1

OMIM:605568 SMURF1

UCSC:Q9HCE7 SMURF1

Reference Transcript

Other Identifiers

0002480537

0004760452

11722957_a_at

11736974_a_at

17060186

212666_at

212668_at

215458_s_at

3063088

3063089

3063090

3063091

3063092

3063093

3063094

3063096

3063097

3063098

3063100

3063102

3063105

3063107

3063109

3063111

3063114

3063115

3063116

3063117

3063118

3063119

3063120

3063122

3063124

3063156

3063157

37504_at

57154

63399_at

8141241

A_23_P353316

A_23_P398254

GE56944

GO:0000209

GO:0000902

GO:0003674

GO:0004842

GO:0005515

GO:0005543

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006464

GO:0006511

GO:0006605

GO:0006611

GO:0006810

GO:0006913

GO:0006914

GO:0007034

GO:0007165

GO:0007179

GO:0007267

GO:0007398

GO:0008150

GO:0008289

GO:0009056

GO:0015031

GO:0016020

GO:0016567

GO:0016740

GO:0022607

GO:0030154

GO:0030424

GO:0030509

GO:0030512

GO:0030514

GO:0030579

GO:0032801

GO:0034394

GO:0040007

GO:0043025

GO:0043161

GO:0043167

GO:0043226

GO:0045732

GO:0048185

GO:0048856

GO:0060071

GO:0061024

GO:0061630

GO:0061736

GO:0061753

GO:0070062

GO:0070411

GO:0070412

GO:0071211

GO:0072659

GO:1903861

GO:2000060

HMNXSV003028849

Hs.119120.0.S2_3p_at

Hs.119120.1.S1_3p_a_at

ILMN_1721667

ILMN_1737672

ILMN_1756615

ILMN_1779492

PH_hs_0040932

TC07001639.hg

Participates

as a member of

SMURF [nucleoplasm] (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

SMURF1 [cytosol]

Inferred To

Smurf [nucleoplasm] (Drosophila melanogaster)

smurf1 [nucleoplasm] (Danio rerio)

SMURF1 [nucleoplasm] (Bos taurus)

SMURF1 [nucleoplasm] (Canis familiaris)

SMURF1 [nucleoplasm] (Gallus gallus)

SMURF1 [nucleoplasm] (Sus scrofa)

Smurf1 [nucleoplasm] (Mus musculus)

Smurf1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_851994.1, NP_001186776.1, NP_065162.1

OpenTargets

ENSG00000198742

IntEnz

2.3.2.26

GeneCards

Q9HCE7

HPA

ENSG00000198742-SMURF1

Ensembl

ENSG00000198742, ENSP00000355326, ENSP00000491036, ENSP00000492201, ENST00000638647, ENSP00000354621, ENST00000361125, ENST00000638461, ENST00000361368, ENSG00000284126

PRO

Q9HCE7

HMDB Protein

HMDBP09298

PDB

3PYC, 2LAZ, 2LB1, 2LB0, 2LTX

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.645	6
UniProt:Q53GL0 PKHO1			0.623	2
UniProt:P61289 PSME3	2	PSME3 [cytosol] (R-HSA-68816) PSME3 [nucleoplasm] (R-HSA-174310)	0.593	5
UniProt:Q15797 SMAD1	4	SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.573	2
UniProt:Q9Y5W3 KLF2			0.508	2