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SMURF1 [nucleoplasm]
Stable Identifier
R-HSA-3004548
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
SMURFs ubiquitinate RUNX3 (Homo sapiens)
SMURF [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7 binds to SMURF1 (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1:XPO1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)
SMAD7:SMURF1:XPO1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
SMURF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCE7 SMURF1
Gene Names
SMURF1, KIAA1625
Chain
chain:1-757
Reference Genes
BioGPS Gene:57154 SMURF1
COSMIC (genes):SMURF1 SMURF1
CTD Gene:57154 SMURF1
dbSNP Gene:57154 SMURF1
ENSEMBL:ENSG00000198742 SMURF1
HGNC:16807 SMURF1
KEGG:hsa:57154 SMURF1
Monarch:57154 SMURF1
NCBI Gene:57154 SMURF1
OMIM:605568 SMURF1
UCSC:Q9HCE7 SMURF1
Reference Transcript
RefSeq:NM_181349.2 SMURF1
RefSeq:NM_001199847.1 SMURF1
RefSeq:NM_020429.2 SMURF1
Participates
as a member of
SMURF [nucleoplasm] (Homo sapiens)
as a component of
Smad7:SMURF1 [nucleoplasm] (Homo sapiens)
SMAD7:SMURF1 [nucleoplasm] (Homo sapiens)
as an input of
Smad7 binds SMURF1 (Homo sapiens)
SMAD7 binds to SMURF1 (Homo sapiens)
Other forms of this molecule
SMURF1 [cytosol]
Inferred To
Smurf [nucleoplasm]
(Drosophila melanogaster)
smurf1 [nucleoplasm]
(Danio rerio)
SMURF1 [nucleoplasm]
(Bos taurus)
SMURF1 [nucleoplasm]
(Canis familiaris)
SMURF1 [nucleoplasm]
(Gallus gallus)
SMURF1 [nucleoplasm]
(Sus scrofa)
Smurf1 [nucleoplasm]
(Mus musculus)
Smurf1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_851994.1
,
NP_065162.1
,
NP_001186776.1
ENSEMBL
ENST00000361368
,
ENSP00000355326
,
ENSP00000354621
,
ENST00000361125
,
ENSG00000198742
OpenTargets
ENSG00000198742
IntEnz
2.3.2.26
GeneCards
SMURF1
HPA
ENSG00000198742-SMURF1
PRO
Q9HCE7
Pharos - Targets
Q9HCE7
HMDB Protein
HMDBP09298
PDB
2LAZ
,
2LB1
,
3PYC
,
2LB0
,
2LTX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.645
6
UniProt:Q53GL0 PKHO1
0.623
2
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.593
5
UniProt:Q15797 SMAD1
4
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.573
2
UniProt:Q9Y5W3 KLF2
0.508
2
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