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GRIA2 [plasma membrane]
Stable Identifier
R-HSA-3004502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glutamate receptor 2, GRIA2_HUMAN, GluR2
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Long-term potentiation (Homo sapiens)
CaMKII phosphorylates AMPA receptor (Homo sapiens)
Ca impermeable GRIA1:GRIA2 AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Ca impermeable p-S849-GRIA1:GRIA2 AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
p-S849-GRIA1:GRIA2 AMPA receptor [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (Homo sapiens)
Activation of AMPA receptors (Homo sapiens)
Activation of Ca impermeable AMPA receptors (Homo sapiens)
Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptor ligand binding (Homo sapiens)
Ca impermeable AMPA receptor ligand complex [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Trafficking of AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
Trafficking of GluR2-containing AMPA receptors to synapse (Homo sapiens)
Ca impermeable AMPA receptors [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
GRIA2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42262 GRIA2
Gene Names
GRIA2, GLUR2, GLUR2
Chain
signal peptide:1-24, chain:25-883
Reference Genes
BioGPS Gene:2891 GRIA2
COSMIC (genes):GRIA2 GRIA2
CTD Gene:2891 GRIA2
dbSNP Gene:2891 GRIA2
ENSEMBL:ENSG00000120251 GRIA2
HGNC:4572 GRIA2
KEGG:hsa:2891 GRIA2
Monarch:2891 GRIA2
NCBI Gene:2891 GRIA2
OMIM:138247 GRIA2
UCSC:P42262 GRIA2
Reference Transcript
RefSeq:NM_001083620.1 GRIA2
RefSeq:NM_001083619.1 GRIA2
RefSeq:XM_017008117.1 GRIA2
RefSeq:NM_000826.3 GRIA2
RefSeq:XM_017008116.1 GRIA2
Other Identifiers
11721263_at
11721264_a_at
16971822
205358_PM_at
205358_at
236538_PM_at
236538_at
241172_PM_at
241172_at
2749218
2749219
2749223
2749224
2749225
2749226
2749227
2749228
2749229
2749230
2749231
2749232
2749243
2749244
2749245
2749246
2749247
2749248
2749250
2749254
2749255
2749256
2749257
2749258
2749259
2749260
2749261
2749262
2749263
2749269
2749270
2749271
2749276
2749277
2749278
2749279
2749280
2749281
2749282
2749283
2749284
2749285
2749286
2749287
2749288
2749289
2749290
2749291
2749292
2749293
2749294
2749295
2891
40746_at
73227_r_at
73450_at
8098021
91659_at
A_14_P134253
A_23_P340617
A_24_P914688
A_32_P172339
A_33_P3230161
GE57666
GO:0001540
GO:0004970
GO:0004971
GO:0005215
GO:0005216
GO:0005515
GO:0005886
GO:0006811
GO:0007165
GO:0007215
GO:0007268
GO:0009897
GO:0014069
GO:0015276
GO:0016020
GO:0022824
GO:0023052
GO:0030425
GO:0030666
GO:0031090
GO:0032279
GO:0032281
GO:0034220
GO:0035235
GO:0035249
GO:0038023
GO:0043025
GO:0043197
GO:0043226
GO:0045202
GO:0045211
GO:0050804
GO:0055085
GO:0060076
GO:0060078
GO:0060089
GO:0098655
GO:0098794
GO:0098839
GO:0098843
GO:0099094
GO:1904315
HMNXSV003056960
Hs.161378.0.A1_3p_at
Hs.225106.0.A1_3p_at
ILMN_1660372
L20814_at
PH_hs_0023863
TC04000799.hg
g4758479_3p_at
Participates
as an output of
GRIA2 gene expression is inhibited by MECP2:SIN3A complex (Homo sapiens)
as a component of
p-S849-GRIA1:GRIA2 AMPA receptor [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (heteromers) [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR2 (homomers) [plasma membrane] (Homo sapiens)
AMPA receptors containing GluR1 and GluR2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-S880-GRIA2 [plasma membrane]
GRIA2 [endocytic vesicle membrane]
Inferred To
glr-4 [plasma membrane]
(Caenorhabditis elegans)
glr-1 [plasma membrane]
(Caenorhabditis elegans)
Ekar [plasma membrane]
(Drosophila melanogaster)
glr-7 [plasma membrane]
(Caenorhabditis elegans)
Ir21a [plasma membrane]
(Drosophila melanogaster)
Ir25a [plasma membrane]
(Drosophila melanogaster)
DmelCG11155 [plasma membrane]
(Drosophila melanogaster)
Homologues of GRIA2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of GRIA2 [plasma membrane]
(Drosophila melanogaster)
GluRIA [plasma membrane]
(Drosophila melanogaster)
glr-6 [plasma membrane]
(Caenorhabditis elegans)
GRIA2 [plasma membrane]
(Bos taurus)
GRIA2 [plasma membrane]
(Caenorhabditis elegans)
GRIA2 [plasma membrane]
(Canis familiaris)
GRIA2 [plasma membrane]
(Gallus gallus)
GRIA2 [plasma membrane]
(Mus musculus)
GRIA2 [plasma membrane]
(Rattus norvegicus)
GRIA2 [plasma membrane]
(Sus scrofa)
GluRIB [plasma membrane]
(Drosophila melanogaster)
glr-5 [plasma membrane]
(Caenorhabditis elegans)
Ir93a [plasma membrane]
(Drosophila melanogaster)
Ir76b [plasma membrane]
(Drosophila melanogaster)
glr-2 [plasma membrane]
(Caenorhabditis elegans)
Ir8a [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
XP_016863605.1
,
XP_016863606.1
,
NP_000817.2
,
NP_001077088.1
,
NP_001077089.1
Guide to Pharmacology - Targets
445
OpenTargets
ENSG00000120251
ENSEMBL
ENST00000645636
,
ENSP00000495569
,
ENST00000264426
,
ENST00000296526
,
ENST00000507898
,
ENSP00000515472
,
ENSP00000426845
,
ENSP00000377403
,
ENSP00000296526
,
ENST00000393815
,
ENST00000703765
,
ENSP00000264426
HPA
ENSG00000120251-GRIA2
ZINC target
P42262
PRO
P42262
Pharos - Targets
P42262
GlyGen
P42262
HMDB Protein
HMDBP07718
PDB
5ZG1
,
5H8S
,
2XHD
,
3RN8
,
5ZG0
,
8I0B
,
5YBG
,
5YBF
,
3UA8
,
5ZG2
,
5ZG3
,
2WJX
,
7F3O
,
2WJW
,
3RNN
,
3R7X
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9EP80 Pick1
3
Pick1 [plasma membrane]
(R-RNO-8858476)
PICK1 [endocytic vesicle membrane]
(R-RNO-417017)
PICK1 [plasma membrane]
(R-RNO-416989)
0.558
2
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.544
2
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