PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1

Stable Identifier
R-HSA-3000434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Conjugation of SUMO1 to MDM2
ReviewStatus
5/5
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PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1
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PML TRIM27, PIAS1, and PIAS2-1 can each SUMOylate MDM2 with SUMO1 at lysine-182 (Miyauchi et al. 2002, Chu and Yang 2011). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).
Literature References
PubMed ID Title Journal Year
20972456 SUMO E3 ligase activity of TRIM proteins

Chu, Y, Yang, X

Oncogene 2011
12393906 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

Miyauchi, Y, Yogosawa, S, Honda, R, Nishida, T, Yasuda, H

J. Biol. Chem. 2002
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Catalyst Activity

SUMO transferase activity of PML,TRIM27,PIAS1,2-1 [nucleoplasm]

Physical Entity
PML,TRIM27,PIAS1,2-1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Bos taurus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Danio rerio)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Gallus gallus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Mus musculus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Rattus norvegicus)
PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1 (Sus scrofa)
Authored
May, B  (2013-01-24)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-01-27)
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