Reactome | RANBP2 SUMOylates PML with SUMO2

RANBP2 SUMOylates PML with SUMO2

Stable Identifier

R-HSA-3000411

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

Synonyms

Conjugation of SUMO2 to PML

ReviewStatus

5/5

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RANBP2 of the nuclear pore complex SUMOylates PML with SUMO2 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998, Tatham et al. 2005). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for UBE2I participates in SUMOylation of PML with SUMO2. SUMO2 colocalizes significantly with PML bodies (Vertegaal et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
9452416	Covalent modification of PML by the sentrin family of ubiquitin-like proteins Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K	J. Biol. Chem.	1998
15608651	Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection Kim, S, Tatham, MH, Chen, Y, Hay, RT, Jaffray, E, Song, J	Nat. Struct. Mol. Biol.	2005
15175327	A proteomic study of SUMO-2 target proteins Andersen, JS, Hay, RT, Ogg, SC, Lamond, AI, Jaffray, E, Rodriguez, MS, Vertegaal, AC, Mann, M	J. Biol. Chem.	2004