UBE2I, HDAC7 SUMOylate PML with SUMO1

Stable Identifier
R-HSA-3000383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to PML
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UBE2I (UBC9) alone and in association with HDAC7 can SUMOylate PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999, Knipscheer et al. 2008). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). Knockdown of HDAC7 reduces the number of PML bodies (Gao et al. 2008).

Literature References
PubMed ID Title Journal Year
9756909 Identification of three major sentrinization sites in PML

Wada, H, Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K

J. Biol. Chem. 1998
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Sixma, TK, Fish, A, Olsen, JV, Klug, H, Pichler, A, Flotho, A, Johnson, ES, van Dijk, WJ, Mann, M, Knipscheer, P

Mol. Cell 2008
18625722 Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation

Shih, HM, Lam, M, Kao, HY, Gao, C, Chakraborty, S, Cheng, X, Liu, Y, Ho, CC, Stanya, KJ, Reineke, E

Mol. Cell. Biol. 2008
9412458 Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1

Sternsdorf, T, Will, H, Jensen, K

J. Cell Biol. 1997
9452416 Covalent modification of PML by the sentrin family of ubiquitin-like proteins

Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K

J. Biol. Chem. 1998
21098080 A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells

Chelbi-Alix, MK, Meloche, S, Bonneil, E, Galisson, F, Courcelles, M, Thibault, P, Mahrouche, L

Mol. Cell Proteomics 2011
10574707 Cell cycle regulation of PML modification and ND10 composition

Sternsdorf, T, Orr, A, van Driel, R, Everett, RD, Lomonte, P

J. Cell. Sci. 1999
9885291 SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation

Lallemand-Breitenbach, V, de Thé, H, Freemont, PS, Duprez, E, Saurin, AJ, Desterro, JM, Solomon, E, Boddy, MN, Hay, RT, Howe, K

J. Cell. Sci. 1999
Participants
Participates
Catalyst Activity

SUMO transferase activity of UBE2I,HDAC7 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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