Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CBLIF [lysosomal lumen]
Stable Identifier
R-HSA-3000272
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
Gastric intrinsic factor, IF_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome (Homo sapiens)
CBLIF:RCbl [lysosomal lumen] (Homo sapiens)
CBLIF [lysosomal lumen] (Homo sapiens)
Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl (Homo sapiens)
CBLIF:RCbl [lysosomal lumen] (Homo sapiens)
CBLIF [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27352 CBLIF
Gene Names
CBLIF, GIF, IFMH
Chain
signal peptide:1-18, chain:19-417
Reference Genes
BioGPS Gene:2694 CBLIF
COSMIC (genes):CBLIF CBLIF
CTD Gene:2694 CBLIF
dbSNP Gene:2694 CBLIF
ENSEMBL:ENSG00000134812 GIF
ENSEMBL_homo_sapiens_GENE:ENSG00000134812.8 CBLIF
HGNC:4268 CBLIF
KEGG Gene (Homo sapiens):2694 CBLIF
Monarch:2694 CBLIF
NCBI Gene:2694 CBLIF
OMIM:609342 CBLIF
UCSC:P27352 CBLIF
Reference Transcript
RefSeq:NM_005142.2 CBLIF
Other Identifiers
11733983_a_at
11748336_a_at
16738786
207033_PM_at
207033_at
2694
32470_at
3374875
3374876
3374879
3374880
3374881
3374884
3374885
3374886
3374887
3374888
3374889
7948433
A_23_P52974
GE80514
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005768
GO:0005773
GO:0005886
GO:0005902
GO:0006811
GO:0006824
GO:0015889
GO:0016324
GO:0031410
GO:0031419
GO:0043202
GO:0043226
GO:0055085
GO:0140355
HMNXSV003042265
ILMN_1731547
M63154_at
PH_hs_0006064
TC11001836.hg
g4826743_3p_at
Participates
as a component of
CBLIF:RCbl [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
CBLIF S27Cfs*23 [extracellular region]
CBLIF [extracellular region]
Inferred To
CBLIF [lysosomal lumen]
(Bos taurus)
CBLIF [lysosomal lumen]
(Canis familiaris)
CBLIF [lysosomal lumen]
(Drosophila melanogaster)
CBLIF [lysosomal lumen]
(Mus musculus)
CBLIF [lysosomal lumen]
(Rattus norvegicus)
CBLIF [lysosomal lumen]
(Sus scrofa)
CBLIF [lysosomal lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005133.2
OpenTargets
ENSG00000134812
GeneCards
P27352
HPA
ENSG00000134812-CBLIF
Ensembl
ENSG00000134812
,
ENSP00000257248
,
ENST00000257248
PRO
P27352
Pharos - Targets
P27352
Orphanet
16124
HMDB Protein
HMDBP01997
PDB
2PMV
,
3KQ4
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60494 CUBN
4
CUBN P1297L [plasma membrane]
(R-HSA-3296479)
CUBN [cytosol]
(R-HSA-350162)
CUBN [lysosomal lumen]
(R-HSA-350088)
CUBN [plasma membrane]
(R-HSA-264843)
0.558
2
UniProt:Q8TBB6 S7A14
0.556
3
UniProt:A1A5C7-2 SLC22A23
0.556
3
UniProt:O15552 FFAR2
1
FFAR2 [plasma membrane]
(R-HSA-443944)
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text