TCN2:RCbl is degraded to release RCbl

Stable Identifier
R-HSA-3000263
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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A lysosomal protease that is sensitive to treatment with chloroquine but otherwise uncharacterized hydrolyzes transcobalamin 2 (TCN2) bound to cobalamins (RCbl), releasing the latter (Youngdahl Turner et al. 1979).

Literature References
PubMed ID Title Journal Year
759210 Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts

Mellman, IS, Youngdahl-Turner, P, Rosenberg, LE, Allen, RH

Exp. Cell Res. 1979
Participants
Participates
Catalyst Activity

peptidase activity of unknown protease [lysosomal lumen]

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