TCN2:RCbl is degraded to release RCbl

Stable Identifier
R-HSA-3000263
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
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TCN2:RCbl is degraded to release RCbl
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A lysosomal protease that is sensitive to treatment with chloroquine but otherwise uncharacterized hydrolyzes transcobalamin 2 (TCN2) bound to cobalamins (RCbl), releasing the latter (Youngdahl Turner et al. 1979).
Literature References
PubMed ID Title Journal Year
759210 Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts

Youngdahl-Turner, P, Mellman, IS, Allen, RH, Rosenberg, LE

Exp. Cell Res. 1979
Participants
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Output
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as an event of
Catalyst Activity

peptidase activity of unknown protease [lysosomal lumen]

Physical Entity
unknown protease [lysosomal lumen] (Homo sapiens)
Activity
peptidase activity (GO:0008233)
Authored
Jassal, B  (2013-01-24)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-24)
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