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TCN2 [lysosomal lumen]
Stable Identifier
R-HSA-3000262
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
TCII, Transcobalamin-2, TCO2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
CD320-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)
TCN2:RCbl [lysosomal lumen] (Homo sapiens)
TCN2 [lysosomal lumen] (Homo sapiens)
LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)
TCN2:RCbl [lysosomal lumen] (Homo sapiens)
TCN2 [lysosomal lumen] (Homo sapiens)
TCN2:RCbl is degraded to release RCbl (Homo sapiens)
TCN2:RCbl [lysosomal lumen] (Homo sapiens)
TCN2 [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20062 TCN2
Gene Names
TCN2, TC2
Chain
signal peptide:1-18, chain:19-427
Reference Genes
BioGPS Gene:6948 TCN2
COSMIC (genes):TCN2 TCN2
CTD Gene:6948 TCN2
dbSNP Gene:6948 TCN2
ENSEMBL:ENSG00000185339 TCN2
HGNC:11653 TCN2
KEGG:hsa:6948 TCN2
Monarch:6948 TCN2
NCBI Gene:6948 TCN2
OMIM:613441 TCN2
UCSC:P20062 TCN2
Reference Transcript
RefSeq:NM_001184726.1 TCN2
RefSeq:NM_000355.3 TCN2
Other Identifiers
11720242_a_at
11720243_x_at
11744645_a_at
16928988
204043_PM_at
204043_at
37922_at
3942473
3942474
3942476
3942477
3942478
3942479
3942480
3942481
3942482
3942483
3942484
3942485
3942486
3942487
3942490
3942491
3942492
3942493
3942494
3942495
3942496
3942498
6948
74878_at
8072360
89946_at
A_14_P111956
A_23_P40611
GE57547
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006824
GO:0009897
GO:0015889
GO:0031419
GO:0043202
GO:0046872
GO:0055085
GO:0140355
ILMN_1740572
L02648_at
PH_hs_0019658
TC22000215.hg
TC22001067.hg
g4507408_3p_at
Participates
as a component of
TCN2:RCbl [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
TCII P259R [extracellular region]
TCN2 [plasma membrane]
TCN2 [extracellular region]
Inferred To
TCN2 [lysosomal lumen]
(Bos taurus)
TCN2 [lysosomal lumen]
(Canis familiaris)
TCN2 [lysosomal lumen]
(Drosophila melanogaster)
TCN2 [lysosomal lumen]
(Gallus gallus)
TCN2 [lysosomal lumen]
(Mus musculus)
TCN2 [lysosomal lumen]
(Rattus norvegicus)
TCN2 [lysosomal lumen]
(Sus scrofa)
TCN2 [lysosomal lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001171655.1
,
NP_000346.2
ENSEMBL
ENST00000215838
,
ENSP00000384914
,
ENSP00000215838
,
ENSG00000185339
,
ENST00000407817
OpenTargets
ENSG00000185339
GeneCards
TCN2
HPA
ENSG00000185339-TCN2
PRO
P20062
Pharos - Targets
P20062
Orphanet
TCN2
HMDB Protein
HMDBP01735
PDB
2BB5
,
7QBG
,
7QBE
,
7QBF
,
5NRP
,
7QBD
,
5NP4
,
5NSA
,
4ZRP
,
4ZRQ
,
5NO0
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.678
11
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