Reactome | TMPO-1 [nuclear envelope]

TMPO-1 [nuclear envelope]

Stable Identifier

R-HSA-2993885

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

LAP2beta, Lamina-associated polypeptide 2, isoform beta, TMPO isoform 1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Nuclear Envelope Breakdown (Homo sapiens)
        
        Depolymerisation of the Nuclear Lamina (Homo sapiens)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)
        
        VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        TMPO-1 [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42167-1 TMPO

Gene Names

TMPO, LAP2

Other Identifiers

11731918_a_at

11731919_a_at

11747091_a_at

11747092_x_at

11763585_s_at

11764010_a_at

16755498

209753_s_at

209754_s_at

224944_at

32682_at

3427776

3427777

3427778

3427779

3427780

3427781

3427788

3427789

3427796

3427797

3427799

3427800

3427802

3427803

3427804

3427805

3427806

3427807

3427808

3427809

3427810

3427811

3427812

3668746

51750_s_at

56493_r_at

7112

7957737

81494_at

A_24_P210244

A_33_P3412613

GE62529

GO:0003674

GO:0003677

GO:0005515

GO:0005521

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005737

GO:0016020

GO:0016021

GO:0031965

GO:0043226

Hs.11355.2.S1_3p_a_at

Hs.11355.4.A1_3p_at

ILMN_1677747

ILMN_1795340

PH_hs_0038319

TC12000761.hg

U09087_s_at

U18271_cds3_s_at

g6855608_3p_a_at

Participant Of

hasCandidate

EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]

Cross References

RefSeq

NP_001027454.1, NP_001027455.1, NP_001294904.1

OpenTargets

ENSG00000120802

GeneCards

P42167

Ensembl

ENSP00000450627, ENSG00000120802, ENST00000556029, ENSP00000376773, ENST00000393053, ENSP00000261210, ENST00000261210

PRO

P42167

Orphanet

17255

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.597	4
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.462	2