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Btn-ACACB [mitochondrial outer membrane]
Stable Identifier
R-HSA-2993858
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
ACC2, Acetyl-CoA carboxylase 2 , ACC-beta, Biotin carboxylase
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine shuttle (Homo sapiens)
Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA (Homo sapiens)
Btn-ACACB [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB [mitochondrial outer membrane] (Homo sapiens)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)
Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB [mitochondrial outer membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
An unknown protease degrades ACACB (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB [mitochondrial outer membrane] (Homo sapiens)
HLCS biotinylates ACACB (Homo sapiens)
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Btn-ACACB [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00763 ACACB
Gene Names
ACACB, ACC2, ACCB
Chain
transit peptide:1-, chain:-2458
Reference Genes
BioGPS Gene:32 ACACB
COSMIC (genes):ACACB ACACB
CTD Gene:32 ACACB
dbSNP Gene:32 ACACB
ENSEMBL:ENSG00000076555 ACACB
HGNC:85 ACACB
Monarch:32 ACACB
NCBI Gene:32 ACACB
OMIM:601557 ACACB
UCSC:O00763 ACACB
Reference Transcript
RefSeq:XM_011538259.2 ACACB
RefSeq:XM_005253876.4 ACACB
RefSeq:XM_006719367.3 ACACB
RefSeq:NM_001093.3 ACACB
Other Identifiers
11720885_at
11744991_a_at
11750636_a_at
1552615_PM_at
1552615_at
1552616_PM_a_at
1552616_a_at
16756649
214584_PM_x_at
214584_x_at
221928_PM_at
221928_at
31530_at
31531_g_at
32
3430960
3430964
3430965
3430966
3430967
3430968
3430969
3430970
3430971
3430974
3430975
3430976
3430977
3430979
3430980
3430981
3430982
3430983
3430984
3430986
3430987
3430988
3430990
3430991
3430992
3430993
3430994
3430995
3430996
3430997
3430999
3431001
3431002
3431007
3431008
3431010
3431012
3431013
3431016
3431018
3431021
3431022
3431023
3431024
3431025
3431026
3431027
3431028
3431029
3431031
3431032
3431033
3431034
3431035
3431036
3431037
3431038
3431039
3431040
3431041
3431042
3431043
3431048
3431049
3431050
3431051
3431052
3431053
3431054
3431055
3431056
3431058
3431059
3431060
3431061
3431062
3431064
3431065
3431066
3431067
3431068
38529_at
43427_PM_at
43427_at
4811882C_3p_s_at
49452_3p_at
49452_PM_at
49452_at
55339_at
7958466
A_14_P113550
A_14_P114701
A_14_P116813
A_14_P124212
A_23_P87791
A_33_P3255329
A_33_P3334220
GE554953
GE59952
GE80460
GO:0003824
GO:0003989
GO:0005515
GO:0005524
GO:0005634
GO:0005739
GO:0005741
GO:0005829
GO:0006084
GO:0006091
GO:0006098
GO:0006163
GO:0006629
GO:0006633
GO:0006790
GO:0007584
GO:0009374
GO:0009410
GO:0010884
GO:0010906
GO:0014070
GO:0016507
GO:0016874
GO:0019395
GO:0031667
GO:0031999
GO:0042802
GO:0043226
GO:0046322
GO:0046323
GO:0046722
GO:0046872
GO:0050995
GO:0051289
GO:0055085
GO:0055086
GO:0060421
GO:0065003
GO:0072350
GO:0090459
GO:0090461
GO:0097009
GO:1901135
GO:1903242
GO:2001295
HMNXSV003024984
HMNXSV003042112
HMNXSV003044836
Hs.183857.0.S2_3p_at
Hs.234898.0.A1_3p_at
Hs.234898.0.A1_3p_x_at
Hs2.183857.1.S1_3p_s_at
ILMN_1763852
PH_hs_0032249
TC12000846.hg
Participates
as a component of
Btn-ACACB:2Mn2+ [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
ACACB [mitochondrial outer membrane]
ACACB [cytosol]
Btn-p-S222-ACACB [mitochondrial outer membrane]
Inferred To
Btn-ACACB [mitochondrial outer membrane]
(Caenorhabditis elegans)
Btn-ACACB [mitochondrial outer membrane]
(Dictyostelium discoideum)
Btn-ACACB [mitochondrial outer membrane]
(Mus musculus)
Btn-ACACB [mitochondrial outer membrane]
(Plasmodium falciparum)
Btn-ACACB [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
Btn-ACACB [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
pod-2 [mitochondrial outer membrane]
(Caenorhabditis elegans)
ACACB [mitochondrial outer membrane]
(Canis familiaris)
ACACB [mitochondrial outer membrane]
(Sus scrofa)
Acacb [mitochondrial outer membrane]
(Rattus norvegicus)
Homologues of Btn-ACACB [mitochondrial outer membrane]
(Caenorhabditis elegans)
Homologues of Btn-ACACB [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
ACACA [mitochondrial outer membrane]
(Bos taurus)
acacb [mitochondrial outer membrane]
(Xenopus tropicalis)
ACC [mitochondrial outer membrane]
(Drosophila melanogaster)
Modified Residues
Name
N6-biotinyl-L-lysine at 929
Coordinate
929
PsiMod Name
N6-biotinyl-L-lysine [MOD:00126]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine.
Cross References
ZINC - Investigational
ACACB_HUMAN
Guide to Pharmacology - Targets
1264
OpenTargets
ENSG00000076555
ENSEMBL
ENST00000377848
,
ENSP00000341044
,
ENSP00000367079
,
ENST00000338432
HPA
ENSG00000076555-ACACB
ZINC - Substances
ACACB_HUMAN
ZINC target
O00763
PRO
O00763
Pharos - Targets
O00763
ZINC - Predictions - Purchasable
ACACB_HUMAN
PDB
3TDC
,
2DN8
,
2KCC
,
3GID
,
2HJW
,
3JRX
,
3JRW
,
3FF6
,
3GLK
,
5KKN
,
4HQ6
HMDB Protein
HMDBP00018
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9CQ20
1
Mid1ip1 [cytosol]
(R-MMU-8867328)
0.642
4
UniProt:P50747 HLCS
8
HLCS G581S [cytosol]
(R-HSA-3325506)
HLCS R508W [cytosol]
(R-HSA-3325442)
HLCS G261Vfs*20 [cytosol]
(R-HSA-3325463)
HLCS V550M [cytosol]
(R-HSA-3325460)
HLCS L237P [cytosol]
(R-HSA-3325514)
HLCS D571N [cytosol]
(R-HSA-3325499)
HLCS L216R [cytosol]
(R-HSA-3325513)
HLCS [cytosol]
(R-HSA-2993867)
0.618
4
UniProt:O00763 ACACB
4
ACACB [mitochondrial outer membrane]
(R-HSA-4167505)
Btn-ACACB [mitochondrial outer membrane]
(R-HSA-2993858)
ACACB [cytosol]
(R-HSA-52493)
Btn-p-S222-ACACB [mitochondrial outer membrane]
(R-HSA-8876892)
0.558
2
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