Reactome | SMC6 [nucleoplasm]

SMC6 [nucleoplasm]

Stable Identifier

R-HSA-2993777

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structural maintenance of chromosomes protein 6, SMC6_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
        
        SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
        
        SMC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96SB8 SMC6

Gene Names

SMC6, SMC6L1

Chain

chain:1-1091

Reference Genes

BioGPS Gene:79677 SMC6

COSMIC (genes):SMC6 SMC6

CTD Gene:79677 SMC6

dbSNP Gene:79677 SMC6

ENSEMBL:ENSG00000163029 SMC6

HGNC:20466 SMC6

Monarch:79677 SMC6

NCBI Gene:79677 SMC6

OMIM:609387 SMC6

UCSC:Q96SB8 SMC6

Reference Transcript

Other Identifiers

11724351_a_at

11724352_a_at

16894740

218781_PM_at

218781_at

236535_PM_at

236535_at

2541945

2541946

2541947

2541948

2541949

2541950

2541951

2541953

2541955

2541956

2541957

2541960

2541962

2541963

2541964

2541965

2541966

2541967

2541968

2541969

2541970

2541971

2541972

2541973

2541974

2541975

2541978

2541979

2541981

2541983

2541986

2541987

2541988

2541989

2541990

2541991

2541997

2541998

2542001

2542022

2542023

2542024

2542025

2542027

42388_at

61714_at

75685_at

79677

8050443

A_23_P209962

A_33_P3247210

GE63278

GO:0000217

GO:0000722

GO:0000724

GO:0000775

GO:0000781

GO:0000803

GO:0003677

GO:0003684

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0006302

GO:0006310

GO:0006325

GO:0006974

GO:0016605

GO:0016607

GO:0016787

GO:0016887

GO:0016925

GO:0030915

GO:0031625

GO:0032200

GO:0032204

GO:0035061

GO:0035861

GO:0043226

GO:0044828

GO:0051984

GO:0090398

GO:0097431

GO:0140588

HMNXSV003040900

HMNXSV003054290

Hs.159452.0.A1_3p_at

PH_hs_0025171

PH_hs_0040628

TC02001605.hg

TC02004076.hg

g13375847_3p_at

Participates

as a component of

SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)

Inferred To

smc6 [nucleoplasm] (Xenopus tropicalis)

Smc6 [nucleoplasm] (Rattus norvegicus)

SMC6 [nucleoplasm] (Bos taurus)

SMC6 [nucleoplasm] (Caenorhabditis elegans)

SMC6 [nucleoplasm] (Dictyostelium discoideum)

SMC6 [nucleoplasm] (Gallus gallus)

SMC6 [nucleoplasm] (Mus musculus)

SMC6 [nucleoplasm] (Saccharomyces cerevisiae)

SMC6 [nucleoplasm] (Schizosaccharomyces pombe)

SMC6 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENST00000448223, ENST00000351948, ENSP00000384539, ENSP00000404092, ENST00000402989, ENSP00000323439

OpenTargets

ENSG00000163029

HPA

ENSG00000163029-SMC6

PRO

Q96SB8

Pharos - Targets

Q96SB8

GlyGen

Q96SB8

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.508	2
UniProt:Q9Y547 HSPB11	2	HSPB11 [ciliary tip] (R-HSA-5625342) HSPB11 [cilium] (R-HSA-5617628)	0.508	2
UniProt:Q9BW83 IFT27	2	IFT27 [ciliary tip] (R-HSA-5625357) IFT27 [cilium] (R-HSA-5617621)	0.508	2
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.483	2