Transfer of SUMO3 from E1 to UBE2I (UBC9)

Stable Identifier
R-HSA-2993769
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Transfer of SUMO3 from E1 to UBE2I (UBC9)
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SUMO3 is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (Tatham et al. 2001, Werner et al. 2009).

Literature References
PubMed ID Title Journal Year
11451954 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9

Vaughan, OA, Tatham, MH, Botting, CH, Naismith, JH, Desterro, JM, Jaffray, E, Hay, RT

J. Biol. Chem. 2001
19107418 Performing in vitro sumoylation reactions using recombinant enzymes

Moutty, MC, Melchior, F, Möller, U, Werner, A

Methods Mol. Biol. 2009
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Catalyst Activity

SUMO transferase activity of UBA2:SAE1 [nucleoplasm]

Physical Entity
UBA2:SAE1 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Inferred From
Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)
Authored
May, B  (2013-01-17)
Reviewed
Garg, AK  (2013-05-16)
Created
May, B  (2013-01-19)
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