Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NSMCE1 [nucleoplasm]
Stable Identifier
R-HSA-2993767
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Non-structural maintenance of chromosomes element 1 homolog, NSE1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
NSMCE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WV22 NSMCE1
Gene Names
NSMCE1, HSPC333, HSPC337
Chain
chain:1-266
Reference Genes
BioGPS Gene:197370 NSMCE1
COSMIC (genes):NSMCE1 NSMCE1
CTD Gene:197370 NSMCE1
dbSNP Gene:197370 NSMCE1
ENSEMBL:ENSG00000169189 NSMCE1
HGNC:29897 NSMCE1
Monarch:197370 NSMCE1
NCBI Gene:197370 NSMCE1
OMIM:617263 NSMCE1
UCSC:Q8WV22 NSMCE1
Reference Transcript
RefSeq:NM_145080.3 NSMCE1
RefSeq:XM_006721023.3 NSMCE1
Other Identifiers
11733049_s_at
11754355_x_at
16825196
197370
224666_PM_at
224666_at
3686082
3686083
3686084
3686085
3686086
3686087
3686088
3686089
3686090
3686094
3686095
3686096
3686097
3686098
3686103
3686104
3686111
3686112
3686113
3686114
3686116
3686117
3686118
3686119
49071_at
64289_at
8000413
A_23_P95823
A_33_P3215059
GE86926
GO:0000724
GO:0000775
GO:0000781
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006310
GO:0006325
GO:0006974
GO:0016740
GO:0016925
GO:0030915
GO:0032204
GO:0043226
GO:0043231
GO:0046872
GO:0046983
GO:0061630
GO:0097431
GO:0140096
GO:0140588
HMNXSV003011137
HMNXSV003054105
Hs.284295.0.S1_3p_at
ILMN_1697962
PH_hs_0014738
TC16000977.hg
Participates
as a component of
SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
Inferred To
Nsmce1 [nucleoplasm]
(Mus musculus)
Nsmce1 [nucleoplasm]
(Rattus norvegicus)
NSMCE1 [nucleoplasm]
(Bos taurus)
NSMCE1 [nucleoplasm]
(Dictyostelium discoideum)
NSMCE1 [nucleoplasm]
(Gallus gallus)
NSMCE1 [nucleoplasm]
(Sus scrofa)
nsmce1 [nucleoplasm]
(Xenopus tropicalis)
nse-1 [nucleoplasm]
(Caenorhabditis elegans)
nse1 [nucleoplasm]
(Schizosaccharomyces pombe)
NSE1 [nucleoplasm]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENSP00000355077
,
ENST00000361439
OpenTargets
ENSG00000169189
HPA
ENSG00000169189-NSMCE1
PRO
Q8WV22
Pharos - Targets
Q8WV22
PDB
5WY5
,
5HVQ
,
2CT0
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text