Reactome | SMC5 [nucleoplasm]

SMC5 [nucleoplasm]

Stable Identifier

R-HSA-2993751

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Structural maintenance of chromosomes protein 5, SMC5_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
        
        SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)
        
        SMC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IY18 SMC5

Gene Names

SMC5, KIAA0594, SMC5L1

Chain

chain:1-1101

Reference Genes

BioGPS Gene:23137 SMC5

COSMIC (genes):SMC5 SMC5

CTD Gene:23137 SMC5

dbSNP Gene:23137 SMC5

ENSEMBL:ENSG00000198887 SMC5

ENSEMBL_homo_sapiens_GENE:ENSG00000198887.9 SMC5

HGNC:20465 SMC5

KEGG Gene (Homo sapiens):23137 SMC5

Monarch:23137 SMC5

NCBI Gene:23137 SMC5

OMIM:609386 SMC5

UCSC:Q8IY18 SMC5

Reference Transcript

RefSeq:NM_015110.3 SMC5

Other Identifiers

11722517_a_at

11722518_a_at

11758523_s_at

17085779

212926_PM_at

212926_at

212927_3p_at

212927_PM_at

212927_at

23137

3125341

3125344

3125346

3174225

3174226

3174227

3174228

3174229

3174230

3174231

3174232

3174233

3174234

3174236

3174237

3174238

3174240

3174242

3174244

3174245

3174246

3174247

3174251

3174252

3174257

3174260

3174262

3174263

3174264

3174266

3174267

3174268

3174269

3174270

3174271

3174294

41379_at

8155770

A_14_P134191

A_23_P146526

A_23_P349615

A_32_P126609

GE53299

GO:0000166

GO:0000217

GO:0000278

GO:0000722

GO:0000724

GO:0000775

GO:0000781

GO:0000803

GO:0003677

GO:0003697

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006281

GO:0006310

GO:0006325

GO:0006974

GO:0007049

GO:0007059

GO:0016605

GO:0016607

GO:0016787

GO:0016887

GO:0016925

GO:0019827

GO:0030054

GO:0030261

GO:0030915

GO:0032200

GO:0032204

GO:0034184

GO:0035061

GO:0035861

GO:0036211

GO:0043226

GO:0044772

GO:0044828

GO:0051301

GO:0051984

GO:0071459

GO:0090398

GO:0140014

GO:0140588

GO:0140657

HMNXSV003020129

Hs.103283.0.A1_3p_at

Hs.103283.0.A2_3p_x_at

ILMN_1757132

PH_hs_0025182

TC09000324.hg

Participates

as a component of

SMC5-SMC6 Complex [nucleoplasm] (Homo sapiens)

Inferred To

Smc5 [nucleoplasm] (Rattus norvegicus)

smc5 [nucleoplasm] (Dictyostelium discoideum)

smc5 [nucleoplasm] (Xenopus tropicalis)

SMC5 [nucleoplasm] (Bos taurus)

SMC5 [nucleoplasm] (Caenorhabditis elegans)

SMC5 [nucleoplasm] (Gallus gallus)

SMC5 [nucleoplasm] (Mus musculus)

SMC5 [nucleoplasm] (Saccharomyces cerevisiae)

SMC5 [nucleoplasm] (Schizosaccharomyces pombe)

SMC5 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_055925.2

OpenTargets

ENSG00000198887

GeneCards

Q8IY18

HPA

ENSG00000198887-SMC5

Ensembl

ENSP00000354957, ENST00000361138, ENSG00000198887

PRO

Q8IY18

Pharos - Targets

Q8IY18

Cite Us!