Reactome | TTPA [cytosol]

TTPA [cytosol]

Stable Identifier

R-HSA-2980979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-tocopherol transfer protein, TTPA_HUMAN

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External Reference Information

External Reference

UniProt:P49638 TTPA

Gene Names

TTPA, TPP1

Chain

chain:1-278

Reference Genes

BioGPS Gene:7274 TTPA

COSMIC (genes):TPP1 TTPA

COSMIC (genes):TTPA TTPA

CTD Gene:7274 TTPA

dbSNP Gene:7274 TTPA

ENSEMBL:ENSG00000137561 TTPA

HGNC:12404 TTPA

Monarch:7274 TTPA

NCBI Gene:7274 TTPA

OMIM:600415 TTPA

UCSC:P49638 TTPA

Reference Transcript

RefSeq:NM_000370.3 TTPA

Other Identifiers

11740432_at

17077680

210614_PM_at

210614_at

3137904

3137905

3137906

3137909

3137910

3137911

3137912

3137917

3137918

3137919

34617_at

68907_at

7274

8151042

A_24_P252462

D49488_at

GE57228

GO:0001890

GO:0001892

GO:0005215

GO:0005515

GO:0005546

GO:0005737

GO:0005768

GO:0005770

GO:0005829

GO:0006629

GO:0006766

GO:0008289

GO:0008431

GO:0009636

GO:0031410

GO:0042360

GO:0043226

GO:0043325

GO:0048856

GO:0051180

GO:0061024

GO:0090212

GO:0120009

GO:0120013

GO:1900223

GO:1902936

HMNXSV003051034

ILMN_1741862

ILMN_1749417

ILMN_2160750

PH_hs_0038632

TC08001270.hg

g726181_3p_at

Participates

as an input of

TTPA binds alpha-TOH (Homo sapiens)

as a component of

Inferred To

Dmel\CG2663 [cytosol] (Drosophila melanogaster)

Dmel\CG5958 [cytosol] (Drosophila melanogaster)

Dmel\CG10026 [cytosol] (Drosophila melanogaster)

Dmel\CG33965 [cytosol] (Drosophila melanogaster)

Dmel\CG3823 [cytosol] (Drosophila melanogaster)

Dmel\CG33966 [cytosol] (Drosophila melanogaster)

pinta [cytosol] (Drosophila melanogaster)

BEST:GM01072 [cytosol] (Drosophila melanogaster)

TTPA [cytosol] (Bos taurus)

TTPA [cytosol] (Canis familiaris)

TTPA [cytosol] (Dictyostelium discoideum)

TTPA [cytosol] (Gallus gallus)

TTPA [cytosol] (Mus musculus)

TTPA [cytosol] (Rattus norvegicus)

TTPA [cytosol] (Sus scrofa)

CG15018 [cytosol] (Drosophila melanogaster)

Dmel\CG12926 [cytosol] (Drosophila melanogaster)

CG13241 [cytosol] (Drosophila melanogaster)

CG13770 [cytosol] (Drosophila melanogaster)

Dmel\CG1902 [cytosol] (Drosophila melanogaster)

Dmel\CG10237 [cytosol] (Drosophila melanogaster)

Dmel\CG10301 [cytosol] (Drosophila melanogaster)

Dmel\CG5973 [cytosol] (Drosophila melanogaster)

Dmel\CG10300 [cytosol] (Drosophila melanogaster)

Dmel\CG11550 [cytosol] (Drosophila melanogaster)

Homologues of TTPA [cytosol] (Drosophila melanogaster)

Dmel\CG30339 [cytosol] (Drosophila melanogaster)

Dmel\CG3091 [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000137561

ENSEMBL

ENST00000260116, ENSP00000260116

HPA

ENSG00000137561-TTPA

PRO

P49638

Pharos - Targets

P49638

Orphanet

TTPA

HMDB Protein

HMDBP02033

PDB

1R5L, 5MUG, 6ZPD, 5MUE, 1OIP, 1OIZ

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.556	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q6Q788 APOA5	4	APOA5 [endoplasmic reticulum lumen] (R-HSA-8956716) p-APOA5 [endoplasmic reticulum lumen] (R-HSA-8956979) APOA5 [extracellular region] (R-HSA-174608) APOA5 [cytosol] (R-HSA-6784664)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:P02655 APOC2	3	APOC2 [early endosome] (R-HSA-2429686) APOC2 [cytosol] (R-HSA-2404145) APOC2 [extracellular region] (R-HSA-174699)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q8N5K1 CISD2			0.556	5
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P55327-2 TPD52			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q969L2 MAL2			0.556	5
UniProt:Q8IZR5-2 Q8IZR52			0.556	3
UniProt:Q9NR31 SAR1A			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q9BRK0 REEP2			0.556	3
UniProt:Q5T9G4-2 ARMC12			0.556	3
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.556	3
UniProt:Q7Z769 S35E3			0.556	3
UniProt:Q92915-2 FGF14			0.556	3
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q9Y680 FKBP7			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:Q9NZJ6 COQ3	1	COQ3 [mitochondrial inner membrane] (R-HSA-2162206)	0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:B3EWG3 FM25C			0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525) FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321)	0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:Q8TAC2 JOSD2	1	JOSD2 [cytosol] (R-HSA-5688775)	0.556	3
UniProt:Q02127 DHODH	1	DHODH [mitochondrial inner membrane] (R-HSA-73523)	0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:O95182 NDUFA7	1	NDUFA7 [mitochondrial inner membrane] (R-HSA-59858)	0.556	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3

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