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TCN2 [extracellular region]
Stable Identifier
R-HSA-2980925
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Transcobalamin-2, TCII
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective CD320 causes MMATC (Homo sapiens)
Defective CD320 does not transport extracellular TCII:Cbl to endosome (Homo sapiens)
TCN2:Cbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Transport of RCbl within the body (Homo sapiens)
CD320 binds extracellular TCN2:RCbl (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
LRP2 binds extracellular TCN2:RCbl (Homo sapiens)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
LRP2-mediated TCN2:RCbl uptake and delivery to lysosome (Homo sapiens)
LRP2:LDLRAP1:TCN2:RCbl [plasma membrane] (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
TCN2 binds RCbl in the circulation (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
TCN2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20062 TCN2
Gene Names
TCN2, TC2
Chain
signal peptide:1-18, chain:19-427
Reference Genes
BioGPS Gene:6948 TCN2
COSMIC (genes):TCN2 TCN2
CTD Gene:6948 TCN2
dbSNP Gene:6948 TCN2
ENSEMBL:ENSG00000185339 TCN2
HGNC:11653 TCN2
KEGG:hsa:6948 TCN2
Monarch:6948 TCN2
NCBI Gene:6948 TCN2
OMIM:613441 TCN2
UCSC:P20062 TCN2
Reference Transcript
RefSeq:NM_001184726.1 TCN2
RefSeq:NM_000355.3 TCN2
Other Identifiers
11720242_a_at
11720243_x_at
11744645_a_at
16928988
204043_PM_at
204043_at
37922_at
3942473
3942474
3942476
3942477
3942478
3942479
3942480
3942481
3942482
3942483
3942484
3942485
3942486
3942487
3942490
3942491
3942492
3942493
3942494
3942495
3942496
3942498
6948
74878_at
8072360
89946_at
A_14_P111956
A_23_P40611
GE57547
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006824
GO:0009897
GO:0015889
GO:0031419
GO:0043202
GO:0046872
GO:0055085
GO:0140355
ILMN_1740572
L02648_at
PH_hs_0019658
TC22000215.hg
TC22001067.hg
g4507408_3p_at
Participates
as a component of
TCN2:Cbl [extracellular region] (Homo sapiens)
TCN2:RCbl [extracellular region] (Homo sapiens)
as an input of
TCN2 binds RCbl in the circulation (Homo sapiens)
Other forms of this molecule
TCII P259R [extracellular region]
TCN2 [plasma membrane]
TCN2 [lysosomal lumen]
Inferred To
TCN2 [extracellular region]
(Bos taurus)
TCN2 [extracellular region]
(Canis familiaris)
TCN2 [extracellular region]
(Drosophila melanogaster)
TCN2 [extracellular region]
(Gallus gallus)
TCN2 [extracellular region]
(Mus musculus)
TCN2 [extracellular region]
(Rattus norvegicus)
TCN2 [extracellular region]
(Sus scrofa)
TCN2 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001171655.1
,
NP_000346.2
ENSEMBL
ENST00000407817
,
ENST00000215838
,
ENSP00000215838
,
ENSP00000384914
OpenTargets
ENSG00000185339
HPA
ENSG00000185339-TCN2
PRO
P20062
Pharos - Targets
P20062
Orphanet
TCN2
HMDB Protein
HMDBP01735
PDB
4ZRP
,
4ZRQ
,
7QBF
,
7QBD
,
5NRP
,
5NP4
,
2BB5
,
5NSA
,
7QBG
,
7QBE
,
5NO0
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.678
11
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