Reactome | DHRS4 [endoplasmic reticulum membrane]

DHRS4 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-2980897

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Dehydrogenase/reductase SDR family member 4 ecNumber1.1.1.184/ecNumber, DHRS4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BTZ2 DHRS4

Gene Names

DHRS4, SDR25C2, UNQ851/PRO1800

Chain

chain:1-278

Reference Genes

BioGPS Gene:10901 DHRS4

COSMIC (genes):DHRS4 DHRS4

CTD Gene:10901 DHRS4

dbSNP Gene:10901 DHRS4

ENSEMBL:ENSG00000157326 DHRS4

ENSEMBL_homo_sapiens_GENE:ENSG00000157326.19 DHRS4

ENSEMBL_homo_sapiens_GENE:ENSG00000284807.3 DHRS4

HGNC:16985 DHRS4

KEGG Gene (Homo sapiens):10901 DHRS4

Monarch:10901 DHRS4

NCBI Gene:10901 DHRS4

OMIM:611596 DHRS4

UCSC:Q9BTZ2 DHRS4

Reference Transcript

Other Identifiers

10901

11744805_x_at

11753211_x_at

11756004_s_at

11756015_s_at

11762823_x_at

16782418

218021_PM_at

218021_at

3529310

3529311

3529312

3529313

3529317

3529322

3529323

3529325

3529327

3529330

3529335

3529336

3529337

3529338

3529339

3529351

3529353

3529354

3529355

3529356

3529358

3529360

3529361

3529362

3529363

3529364

3529379

3529380

3529382

3529383

46220_at

7973448

7973458

A_23_P162982

A_33_P3213997

A_33_P3383422

A_33_P3383431

A_33_P3383436

GE55941

GO:0000253

GO:0001758

GO:0003824

GO:0004090

GO:0005634

GO:0005739

GO:0005777

GO:0005778

GO:0005782

GO:0005783

GO:0005789

GO:0005829

GO:0006066

GO:0006629

GO:0008202

GO:0016491

GO:0016655

GO:0018455

GO:0033703

GO:0042180

GO:0042572

GO:0042574

GO:0042802

GO:0043226

GO:0052650

GO:2000379

HMNXSV003030378

HMNXSV003032180

HMNXSV003038237

ILMN_1762666

ILMN_2185884

PH_hs_0036497

PH_hs_0038131

TC14001604.hg

g10337604_3p_at

Participates

as a member of

RDH11,14,DHRS3,DHRS4 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

DHRS4 [peroxisomal matrix]

DHRS4 [cytosol]

Inferred To

Dhrs4 [endoplasmic reticulum membrane] (Drosophila melanogaster)

DHRS4 [endoplasmic reticulum membrane] (Bos taurus)

DHRS4 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

DHRS4 [endoplasmic reticulum membrane] (Canis familiaris)

DHRS4 [endoplasmic reticulum membrane] (Gallus gallus)

DHRS4 [endoplasmic reticulum membrane] (Mus musculus)

DHRS4 [endoplasmic reticulum membrane] (Rattus norvegicus)

DHRS4 [endoplasmic reticulum membrane] (Sus scrofa)

dhrs4 [endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_001269919.1, NP_066284.2, NP_001269918.1, NP_001269917.1, NP_001269920.1, NP_001269916.1

OpenTargets

ENSG00000157326

GeneCards

Q9BTZ2

HPA

ENSG00000157326-DHRS4

Ensembl

ENSP00000496426, ENST00000397075, ENSP00000380265, ENST00000397074, ENST00000646997, ENST00000559632, ENST00000645602, ENSG00000284807, ENSP00000452645, ENSG00000157326, ENST00000647030, ENST00000647154, ENSP00000380264, ENSP00000453367, ENST00000313250, ENSP00000453983, ENST00000558263, ENST00000558581, ENSP00000495868, ENSP00000495877, ENSP00000326219, ENSP00000496349

PRO

Q9BTZ2

Pharos - Targets

Q9BTZ2

HMDB Protein

HMDBP00076

PDB

3O4R

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06865 HEXA	3	HEXA Y427Ifs*5 [lysosomal lumen] (R-HSA-3700918) HEXA(88-528) [lysosomal lumen] (R-HSA-1605799) HEXA(23-73) [lysosomal lumen] (R-HSA-9842401)	0.527	2
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.527	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	4

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