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DIO2 [plasma membrane]
Stable Identifier
R-HSA-2980836
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Type II iodothyronine deiodinase, IOD2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
DIO2 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Regulation of thyroid hormone activity (Homo sapiens)
Thyroxine is deiodinated to triiodothyronine (Homo sapiens)
DIO dimer [plasma membrane] (Homo sapiens)
DIO2 homodimer [plasma membrane] (Homo sapiens)
DIO2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92813 DIO2
Gene Names
DIO2, ITDI2, TXDI2
Chain
chain:1-273
Reference Genes
BioGPS Gene:1734 DIO2
COSMIC (genes):DIO2 DIO2
CTD Gene:1734 DIO2
dbSNP Gene:1734 DIO2
ENSEMBL:ENSG00000211448 DIO2
HGNC:2884 DIO2
KEGG:hsa:1734 DIO2
Monarch:1734 DIO2
NCBI Gene:1734 DIO2
OMIM:601413 DIO2
UCSC:Q92813 DIO2
Reference Transcript
RefSeq:NM_001007023.4 DIO2
RefSeq:NM_000793.5 DIO2
RefSeq:NM_001242503.2 DIO2
RefSeq:NM_001324462.1 DIO2
RefSeq:NM_013989.4 DIO2
RefSeq:NM_001242502.2 DIO2
Other Identifiers
11721579_a_at
11721580_a_at
11733463_a_at
11741639_a_at
11749826_a_at
16795285
1734
203699_PM_s_at
203699_s_at
203700_PM_s_at
203700_s_at
210819_PM_x_at
210819_x_at
211215_PM_x_at
211215_x_at
31902_at
3573877
3573878
3573879
3573880
3573881
3573882
3573883
3573884
3573885
3573887
3573888
3573891
3573892
3573893
3573894
3573896
3573904
3573906
3573907
7980485
A_23_P48740
A_24_P341674
A_33_P3325700
GE61010
GO:0001514
GO:0003824
GO:0004800
GO:0005886
GO:0006575
GO:0006590
GO:0008430
GO:0016020
GO:0016491
GO:0031625
GO:0032496
GO:0033798
GO:0042403
GO:0042446
GO:0120162
HMNXSV003030539
HMNXSV003032044
HMNXSV003039885
ILMN_1737650
PH_hs_0025465
TC14001364.hg
TC14001365.hg
U53506_at
g10863066_3p_a_at
g1518541_3p_a_at
g7549802_3p_a_at
Participates
as an output of
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
as a component of
DIO2 homodimer [plasma membrane] (Homo sapiens)
Inferred To
DIO2 [plasma membrane]
(Bos taurus)
DIO2 [plasma membrane]
(Gallus gallus)
DIO2 [plasma membrane]
(Sus scrofa)
dio3 [plasma membrane]
(Dictyostelium discoideum)
Dio2 [plasma membrane]
(Mus musculus)
Dio2 [plasma membrane]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2482
ENSEMBL
ENSP00000405854
,
ENSG00000211448
,
ENSP00000451419
,
ENST00000438257
,
ENST00000557010
OpenTargets
ENSG00000211448
GeneCards
DIO2
HPA
ENSG00000211448-DIO2
PRO
Q92813
Pharos - Targets
Q92813
HMDB Protein
HMDBP01062
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