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DIO1 [plasma membrane]
Stable Identifier
R-HSA-2980823
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Type I iodothyronine deiodinase, IOD1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Regulation of thyroid hormone activity (Homo sapiens)
Thyroxine is deiodinated to triiodothyronine (Homo sapiens)
DIO dimer [plasma membrane] (Homo sapiens)
DIO1 homodimer [plasma membrane] (Homo sapiens)
DIO1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49895 DIO1
Gene Names
DIO1, ITDI1, TXDI1
Chain
chain:1-249
Reference Genes
BioGPS Gene:1733 DIO1
COSMIC (genes):DIO1 DIO1
CTD Gene:1733 DIO1
dbSNP Gene:1733 DIO1
ENSEMBL:ENSG00000211452 DIO1
HGNC:2883 DIO1
KEGG:hsa:1733 DIO1
Monarch:1733 DIO1
NCBI Gene:1733 DIO1
OMIM:147892 DIO1
UCSC:P49895 DIO1
Reference Transcript
RefSeq:NM_001324316.1 DIO1
RefSeq:NM_001039716.2 DIO1
RefSeq:NM_001039715.2 DIO1
RefSeq:NM_000792.6 DIO1
RefSeq:NM_213593.4 DIO1
Other Identifiers
11729360_a_at
11729361_x_at
11729362_a_at
11737601_a_at
11753711_x_at
11753737_a_at
11753738_x_at
16664897
1733
206457_PM_s_at
206457_s_at
2336892
2336893
2336894
2336895
2336896
2336897
2336898
2336899
2336900
2336901
2336902
2336903
2336904
2336905
2336906
2336908
2336909
2336910
31966_at
7901565
A_14_P124846
A_23_P45811
GE62112
GO:0003824
GO:0004800
GO:0005783
GO:0005789
GO:0005886
GO:0006520
GO:0006575
GO:0006590
GO:0008430
GO:0016020
GO:0016491
GO:0042403
GO:0042446
GO:0043226
HMNXSV003040843
ILMN_1686291
ILMN_1769547
ILMN_2414786
PH_hs_0013306
TC01000658.hg
g4557521_3p_s_at
Participates
as a component of
DIO1 homodimer [plasma membrane] (Homo sapiens)
Inferred To
dio3 [plasma membrane]
(Dictyostelium discoideum)
Dio1 [plasma membrane]
(Mus musculus)
Dio1 [plasma membrane]
(Rattus norvegicus)
DIO1 [plasma membrane]
(Canis familiaris)
DIO1 [plasma membrane]
(Gallus gallus)
DIO1 [plasma membrane]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
2481
ENSEMBL
ENSP00000323198
,
ENST00000388876
,
ENSP00000435725
,
ENSP00000354643
,
ENST00000532493
,
ENST00000322679
,
ENSP00000434758
,
ENST00000525202
,
ENSG00000211452
,
ENSP00000373528
,
ENST00000361921
OpenTargets
ENSG00000211452
GeneCards
DIO1
HPA
ENSG00000211452-DIO1
PRO
P49895
Pharos - Targets
P49895
HMDB Protein
HMDBP01061
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