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CCR2 [plasma membrane]
Stable Identifier
R-HSA-2976755
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
C-C chemokine receptor type 2, CCR2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-10 signaling (Homo sapiens)
IL10 positively regulates plasma membrane-associated inflammatory mediators (Homo sapiens)
IL10-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Defensins (Homo sapiens)
Beta defensins (Homo sapiens)
Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)
Beta defensins 4A,103:CCR2 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CCR2, CCR3 bind CCL13 (Homo sapiens)
CCL13:CCL2,CCR3 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
Receptors CCR1, 2 and 8 bind CCL16 ligand (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
CCR1,2,8:CCL16 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
CCR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41597 CCR2
Gene Names
CCR2, CMKBR2
Chain
chain:1-374
Reference Genes
BioGPS Gene:729230 CCR2
COSMIC (genes):CCR2 CCR2
CTD Gene:729230 CCR2
dbSNP Gene:729230 CCR2
ENSEMBL:ENSG00000121807 CCR2
HGNC:1603 CCR2
KEGG:hsa:729230 CCR2
Monarch:729230 CCR2
NCBI Gene:729230 CCR2
OMIM:601267 CCR2
UCSC:P41597 CCR2
Reference Transcript
RefSeq:XM_011534069.1 CCR2
RefSeq:NM_001123041.2 CCR2
RefSeq:NM_001123396.1 CCR2
Other Identifiers
11731676_s_at
11750769_s_at
11750856_s_at
11752590_s_at
16940172
206978_PM_at
206978_at
207794_PM_at
207794_at
2620844
2620845
2620846
2620847
2620848
2620849
2620850
2620851
2620852
39936_at
39937_at
39938_g_at
4047164
4047165
4047166
4047167
4047168
4047169
4047170
729230
8079392
8093294
A_23_P212354
A_23_P324885
A_24_P11825
GE80933
GO:0001650
GO:0001974
GO:0002376
GO:0002407
GO:0002548
GO:0002724
GO:0002827
GO:0002829
GO:0004930
GO:0004950
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006874
GO:0006935
GO:0006954
GO:0006955
GO:0006959
GO:0006968
GO:0007155
GO:0007165
GO:0007186
GO:0007194
GO:0007204
GO:0007259
GO:0009611
GO:0009897
GO:0010574
GO:0010820
GO:0016020
GO:0016192
GO:0016493
GO:0016525
GO:0019221
GO:0019233
GO:0019722
GO:0019725
GO:0019955
GO:0019957
GO:0030097
GO:0030425
GO:0031727
GO:0032729
GO:0032743
GO:0032760
GO:0035696
GO:0035705
GO:0035715
GO:0035716
GO:0035717
GO:0042802
GO:0043025
GO:0043204
GO:0043310
GO:0045580
GO:0046641
GO:0048471
GO:0048856
GO:0048870
GO:0048873
GO:0050727
GO:0050729
GO:0050870
GO:0050877
GO:0051968
GO:0060089
GO:0060326
GO:0061756
GO:0070098
GO:0071675
GO:0090026
GO:0090265
GO:0090594
GO:0097350
GO:0120162
GO:1903238
GO:1904783
GO:1905517
GO:1905521
GO:2000404
GO:2000412
GO:2000439
GO:2000451
GO:2000464
GO:2000473
HMNXSV003004101
ILMN_1658299
ILMN_1669062
ILMN_1774761
ILMN_1777461
ILMN_2276996
ILMN_2376431
PH_hs_0026960
PH_hs_0028602
TC03000255.hg
U03905_at
U95626_rna1_at
g4757937_3p_at
g4827072_3p_at
Participates
as a member of
IL10-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
CCR2,CCR3 [plasma membrane] (Homo sapiens)
CCR1,2,8 [plasma membrane] (Homo sapiens)
as a component of
Beta defensins 4A,103:CCR2 [plasma membrane] (Homo sapiens)
as an input of
Beta-defensins 4A and 103 bind CCR2 (Homo sapiens)
Inferred To
npr-32 [plasma membrane]
(Caenorhabditis elegans)
ccr2 [plasma membrane]
(Xenopus tropicalis)
CCR2 [plasma membrane]
(Bos taurus)
CCR2 [plasma membrane]
(Canis familiaris)
CCR2 [plasma membrane]
(Gallus gallus)
CCR2 [plasma membrane]
(Sus scrofa)
Homologues of CCR2 [plasma membrane]
(Gallus gallus)
CCR5 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
XP_011532371.1
,
NP_001116868.1
,
NP_001116513.2
ZINC - World Drugs
CCR2_HUMAN
Guide to Pharmacology - Targets
59
ENSEMBL
ENSP00000383681
,
ENST00000400888
,
ENSP00000399285
,
ENST00000445132
OpenTargets
ENSG00000121807
ZINC - FDA approved
CCR2_HUMAN
ZINC - Substances
CCR2_HUMAN
ZINC - Biogenic
CCR2_HUMAN
ZINC target
P41597
PRO
P41597
GlyGen
P41597
PDB
2MLQ
,
2MLO
,
7XA3
,
7P8X
,
5T1A
ZINC - Investigational
CCR2_HUMAN
HPA
ENSG00000121807-CCR2
Pharos - Targets
P41597
ZINC - Predictions - Purchasable
CCR2_HUMAN
HMDB Protein
HMDBP07575
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6S8J3 POTEE
1
POTEE [cytosol]
(R-HSA-9715126)
0.589
2
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