NOTCH2 coactivator complex binds FCER2 promoter

Stable Identifier
R-HSA-2976742
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH2 coactivator complex binds FCER2 promoter
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The promoter of FCER2 (CD23A) contains several RBPJ (CSL i.e. CBF) binding sites that are occupied by RBPJ transcription complexes that contain NICD2, but not NICD1. The association of NICD2 with RBPJ promoter elements of FCER2 gene was demonstrated by electromobility shift assays on nuclear extracts of human B-cell chronic lymphocytic leukemia (B-CLL) cells (Hubmann et al. 2002).
Literature References
PubMed ID Title Journal Year
11986231 Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

Shehata, M, Berger, R, Schwarzmeier, JD, Duechler, M, Hilgarth, M, Hubmann, R, Dettke, M

Blood 2002
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Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2013-01-10)
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